{"id":"W3164945230","doi":"10.2147/dddt.s299591","title":"A Review of Romiplostim Mechanism of Action and Clinical Applicability","year":2021,"lang":"en","type":"review","venue":"Drug Design Development and Therapy","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Amgen","keywords":"Romiplostim; Thrombopoietin; Medicine; Eltrombopag; Aplastic anemia; Megakaryocyte; Thrombopoietin receptor; Platelet; Internal medicine; Immunology; Oncology; Haematopoiesis; Bone marrow; Stem cell; Immune thrombocytopenia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000547007,0.0006953756,0.001070858,0.002117073,0.0002283366,0.0009238568,0.0007844873,0.0008545077,0.005199693],"category_scores_gemma":[0.0008941073,0.0002616434,0.0008944634,0.001558498,0.0002362236,0.001345958,0.0004206799,0.001568387,0.002167853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005221659,"about_ca_system_score_gemma":0.0009492718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000718826,"about_ca_topic_score_gemma":0.0008967731,"domain_scores_codex":[0.9998016,0.00003350723,0.0000524455,0.0000335616,0.00005904259,0.00001997205],"domain_scores_gemma":[0.9997014,0.0001281308,0.00006452858,0.00000855347,0.00006925976,0.00002808218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004237556,0.0001641085,0.0004088976,0.02595196,0.0001922663,0.0005435098,0.00008006242,0.0005028387,0.004583217,0.002613643,0.04288653,0.9216492],"study_design_scores_gemma":[0.00007429525,0.0004966954,0.001105304,0.003434533,0.0003670525,0.002897997,0.00004169204,0.0001958073,0.001675401,0.0008400338,0.9888399,0.00003113867],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00052602,0.9964945,0.0003064437,0.0004194897,0.0002933668,0.00001900631,0.00009443457,0.00002071412,0.001825968],"genre_scores_gemma":[0.002365514,0.9947138,0.0005047758,0.0005420846,0.0004234836,0.00003025794,0.0001922535,0.000005915463,0.001221884],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005199693,"threshold_uncertainty_score":0.01739472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1612710011089491,"score_gpt":0.4099109441596687,"score_spread":0.2486399430507195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}