{"id":"W3164967630","doi":"10.1038/s41565-021-00898-0","title":"The current landscape of nucleic acid therapeutics","year":2021,"lang":"en","type":"review","venue":"Nature Nanotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1288,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; iCo Therapeutics (Canada); University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Huntington Society of Canada; Government of Canada; Fondation Brain Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute; Canadian Institutes of Health Research; NanoMedicines Innovation Network","keywords":"Nucleic acid; Computational biology; Oligonucleotide; Translation (biology); RNA interference; Small interfering RNA; Nanotechnology; Biology; RNA; Computer science; Bioinformatics; DNA; Gene; Genetics; Messenger RNA; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006930356,0.0008406514,0.0009800522,0.00146154,0.0003354924,0.001205023,0.0008607535,0.001556085,0.006734475],"category_scores_gemma":[0.0008522462,0.0003013702,0.0003775757,0.001402114,0.0005950902,0.001767761,0.0008497771,0.00230904,0.003735807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008344818,"about_ca_system_score_gemma":0.001400201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006979154,"about_ca_topic_score_gemma":0.001034061,"domain_scores_codex":[0.9996808,0.00006115448,0.00003512497,0.00004728817,0.0001429697,0.00003263511],"domain_scores_gemma":[0.9995765,0.000226093,0.00004012884,0.00001343653,0.00010187,0.00004196032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005349952,0.00007121568,0.00008180982,0.01232313,0.00003143623,0.0001805862,0.00006881251,0.0004028263,0.003123542,0.009732685,0.03332278,0.9406077],"study_design_scores_gemma":[0.000006354446,0.00004580414,0.0001281638,0.001465495,0.00001930287,0.0004225162,0.00002589576,0.00006294305,0.0004709139,0.002176399,0.9951676,0.000008717098],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001205138,0.9959627,0.0003136293,0.0006317752,0.0003058651,0.000006092189,0.000017003,0.00001684752,0.002625713],"genre_scores_gemma":[0.0007678684,0.996778,0.0004150297,0.0004505347,0.0002580169,0.00001296091,0.00003468705,0.000003073201,0.001279978],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006734475,"threshold_uncertainty_score":0.02252901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175569821485688,"score_gpt":0.3225202002510293,"score_spread":0.3049632181024605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}