{"id":"W3164978296","doi":"10.1038/s41416-021-01440-8","title":"New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer","year":2021,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Health and Medical Research Council; Bundesministerium für Gesundheit; Bundeszentrale für gesundheitliche Aufklärung; University of Oxford; Health Technology Assessment Programme; University College London; Menzies Centre for Australian Studies, King's College London, University of London; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Queen Mary University of London","keywords":"Medicine; Lumpectomy; Intraoperative radiotherapy; Breast cancer; External beam radiotherapy; Cancer; Radiation therapy; Radiology; Oncology; Surgery; Mastectomy; Internal medicine; Brachytherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177621,0.0001131839,0.0003655655,0.00001300088,0.00007667566,0.00004105037,0.0001544718,0.00009459932,0.0001781051],"category_scores_gemma":[0.0001370198,0.00008356675,0.0002163173,0.00004466404,0.0001414426,0.00001060428,0.00004950053,0.000119476,5.336787e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003561074,"about_ca_system_score_gemma":0.0003986394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004564099,"about_ca_topic_score_gemma":0.001120417,"domain_scores_codex":[0.998957,0.0001161032,0.0004697439,0.0002093955,0.0001383546,0.0001094308],"domain_scores_gemma":[0.9990708,0.000111438,0.0002858733,0.00007774255,0.0003849749,0.00006919261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3299908,0.0005927385,0.07622536,0.00002243823,0.01041149,0.0001325172,0.0006615905,0.0001175577,0.280141,0.00003406987,0.01329295,0.2883775],"study_design_scores_gemma":[0.33258,0.0003523172,0.5912188,0.0002754747,0.0002214082,0.0003608023,0.0002135317,0.00001334463,0.05819025,0.0001609006,0.0161715,0.0002416285],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9354082,0.0607288,0.0003557444,0.00187146,0.0009389233,0.0002286088,0.0004534408,0.000001971672,0.00001286874],"genre_scores_gemma":[0.9332945,0.06116501,0.001056661,0.0003727965,0.003970129,0.00004552343,0.0000248725,0.00001379457,0.00005666066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5149935,"threshold_uncertainty_score":0.3407753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015317250788076,"score_gpt":0.3090332143041405,"score_spread":0.2937159635160645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}