{"id":"W3164978296","doi":"10.1038/s41416-021-01440-8","title":"New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer","year":2021,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Health and Medical Research Council; Bundesministerium für Gesundheit; Bundeszentrale für gesundheitliche Aufklärung; University of Oxford; Health Technology Assessment Programme; University College London; Menzies Centre for Australian Studies, King's College London, University of London; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Queen Mary University of London","keywords":"Medicine; Lumpectomy; Intraoperative radiotherapy; Breast cancer; External beam radiotherapy; Cancer; Radiation therapy; Radiology; Oncology; Surgery; Mastectomy; Internal medicine; Brachytherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02282141,0.001458674,0.001978892,0.00047525,0.0001447159,0.001320206,0.0009518081,0.0009559191,0.007991959],"category_scores_gemma":[0.03032011,0.0002626251,0.005075323,0.0007152784,0.0005781361,0.001167841,0.000875127,0.002159022,0.0005343815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000404814,"about_ca_system_score_gemma":0.0008645377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007456928,"about_ca_topic_score_gemma":0.001265802,"domain_scores_codex":[0.9856876,0.01253037,0.0004272333,0.0005516578,0.0005366933,0.0002665019],"domain_scores_gemma":[0.9699966,0.02406439,0.003132004,0.001779706,0.0004417888,0.0005854241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5688159,0.002537251,0.08119746,0.0105786,0.04940761,0.0004708686,0.0005381474,0.0190177,0.004874256,0.007376256,0.01090308,0.2442828],"study_design_scores_gemma":[0.3120441,0.09868468,0.2979536,0.002935376,0.1396734,0.001069608,0.0005130897,0.04259047,0.002688929,0.03738883,0.0640742,0.000383733],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8591157,0.09100655,0.0145947,0.01193288,0.002135877,0.001242858,0.008591975,0.0002575046,0.01112193],"genre_scores_gemma":[0.9741735,0.007198671,0.004476851,0.003308527,0.001204033,0.0007800383,0.005547952,0.00008521348,0.003225145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02282141,"threshold_uncertainty_score":0.1206926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015317250788076,"score_gpt":0.3090332143041405,"score_spread":0.2937159635160645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}