{"id":"W3164994466","doi":"10.1007/s12013-021-00998-7","title":"Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore","year":2021,"lang":"en","type":"article","venue":"Cell Biochemistry and Biophysics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Divalent; Chemistry; Biophysics; Selectivity; Extracellular; Mutant; Intracellular; Patch clamp; Membrane; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112087,0.0001146275,0.0001454288,0.00001279781,0.00006436101,0.00002665819,0.00007239574,0.00006211549,0.0000115807],"category_scores_gemma":[0.00006316852,0.00008255786,0.00004943912,0.0003113855,0.00009628716,0.00003618079,0.00006879117,0.0002321369,0.000003880141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003444376,"about_ca_system_score_gemma":0.00008581772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007074528,"about_ca_topic_score_gemma":0.00000104878,"domain_scores_codex":[0.9991456,0.00002829585,0.000107476,0.0002775328,0.0002266036,0.0002144413],"domain_scores_gemma":[0.9995059,0.00006399097,0.00003168119,0.0002546152,0.00007109407,0.00007273949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006322619,0.0003723497,0.0008836311,0.0004915811,0.00000856622,0.0001258633,0.0001349856,0.000001530001,0.9950556,0.00001430699,0.0003448519,0.00250349],"study_design_scores_gemma":[0.000506894,0.00007638529,0.004665558,0.00008003032,0.00001737647,0.00006637175,0.0004330612,0.000182869,0.9926702,0.0003136201,0.0008923437,0.00009533834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953517,0.001868478,0.00005512198,0.0008420436,0.00003131621,0.0001275655,0.00002005426,0.00001367471,0.001689989],"genre_scores_gemma":[0.9983876,0.0004178336,0.0001777776,0.0001291119,0.0001756123,0.00001284334,0.0001095724,0.00000716677,0.0005824302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003781927,"threshold_uncertainty_score":0.3366612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118362265584057,"score_gpt":0.2612453013293059,"score_spread":0.2494090747709002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}