{"id":"W3165005869","doi":"10.1172/jci.insight.148855","title":"Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; University of Toronto; Structural Genomics Consortium; Western University","funders":"University of Toronto; London Health Sciences Foundation; Academic Medical Organization of Southwestern Ontario; Lawson Health Research Institute; University of Texas at Austin","keywords":"Epitope; Antibody; Virology; Antigen; Serology; Immunology; Linear epitope; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002395203,0.0001925335,0.0005673038,0.0002036822,0.0001126461,0.00004921543,0.000131903,0.0001346249,0.0001890387],"category_scores_gemma":[0.001102193,0.0001496517,0.0001222706,0.0003501046,0.0002512886,0.00008609576,0.0001833842,0.0002355663,0.000050358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007727385,"about_ca_system_score_gemma":0.0006423171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001059903,"about_ca_topic_score_gemma":0.00002783392,"domain_scores_codex":[0.9981846,0.0002033512,0.0003765635,0.0004337777,0.000487294,0.0003143977],"domain_scores_gemma":[0.9983954,0.0006009351,0.0001150481,0.0005554127,0.0002001981,0.0001329796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006691794,0.0002838448,0.4350376,0.0002393751,0.0001485514,0.001045442,0.0009046799,4.453389e-8,0.558574,0.0009698619,0.0004396772,0.001687838],"study_design_scores_gemma":[0.003379069,0.0002008423,0.3995629,0.00007887348,0.00005846436,0.0001010828,0.0002106175,0.00001985898,0.2428011,0.000350651,0.3530582,0.0001783655],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898621,0.004496029,0.0006224621,0.001730091,0.0002556537,0.0002621595,0.00003866238,0.00005592973,0.002676914],"genre_scores_gemma":[0.9784522,0.0003418325,0.0001809997,0.02023509,0.0001090086,0.00001188684,0.00001610428,0.00002936421,0.0006234809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3526186,"threshold_uncertainty_score":0.6102621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1080357602708922,"score_gpt":0.4043124342308227,"score_spread":0.2962766739599306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}