{"id":"W3165018664","doi":"10.1126/sciimmunol.abd3774","title":"Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 <sup>+</sup> CD8 <sup>+</sup> T <sub>regs</sub>","year":2021,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Stiftelsen Professor Nanna Svartz Fond; Medical Research Council Canada; Ruth och Richard Julins Stiftelse; Kungliga Fysiografiska Sällskapet i Lund; Vetenskapsrådet; Lundbeckfonden; IngaBritt och Arne Lundbergs Forskningsstiftelse; Carl Tryggers Stiftelse för Vetenskaplig Forskning; Cancerfonden; Francis Crick Institute","keywords":"Antigen; FOXP3; CD8; Biology; Cell biology; Molecular biology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168294,0.0003443107,0.0001842527,0.000353184,0.0002491287,0.0004464039,0.0002463935,0.000326097,0.003393315],"category_scores_gemma":[0.0001113788,0.000201161,0.0001781836,0.0001385681,0.0003130868,0.0002207425,0.0003694443,0.001274765,0.0008050335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003842989,"about_ca_system_score_gemma":0.0002667939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007595605,"about_ca_topic_score_gemma":0.002178274,"domain_scores_codex":[0.9998241,0.00001915962,0.000009132591,0.00003654622,0.00004270213,0.00006838778],"domain_scores_gemma":[0.9997609,0.00002450379,0.00005813062,0.00002460427,0.00002363641,0.0001082604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002546041,0.00008762546,0.0004365323,0.00004291689,0.000003100622,0.00006269313,0.00004031723,0.0001286053,0.9956767,0.0004760998,0.0001673318,0.002623524],"study_design_scores_gemma":[0.0000354459,0.0002561231,0.004363001,0.00001182386,0.00001066576,0.0001808961,0.00008404673,0.001537209,0.9890036,0.0001077437,0.004405065,0.000004308569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991375,0.0006530102,0.002191234,0.0001772624,0.00004851207,0.00003466423,0.0005310034,0.0002145894,0.004774771],"genre_scores_gemma":[0.9900878,0.0002078794,0.001605728,0.00005539468,0.00001272715,0.00003287803,0.0003673454,0.00007472005,0.007555561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003393315,"threshold_uncertainty_score":0.01135176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216375226847959,"score_gpt":0.2549406638547016,"score_spread":0.242776911586222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}