{"id":"W3165018664","doi":"10.1126/sciimmunol.abd3774","title":"Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 + CD8 + T regs","year":2021,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Stiftelsen Professor Nanna Svartz Fond; Medical Research Council Canada; Ruth och Richard Julins Stiftelse; Kungliga Fysiografiska Sällskapet i Lund; Vetenskapsrådet; Lundbeckfonden; IngaBritt och Arne Lundbergs Forskningsstiftelse; Carl Tryggers Stiftelse för Vetenskaplig Forskning; Cancerfonden; Francis Crick Institute","keywords":"Antigen; FOXP3; CD8; Biology; Cell biology; Molecular biology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0009013103,0.0004950768,0.0007446932,0.0007235796,0.0009971967,0.0001053091,0.0009563686,0.0005441001,0.001362495],"category_scores_gemma":[0.001301207,0.0004997609,0.0002612221,0.001785912,0.003521172,0.0009737039,0.0005520056,0.00105176,0.002437364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003076429,"about_ca_system_score_gemma":0.0007324421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002418021,"about_ca_topic_score_gemma":0.00001424094,"domain_scores_codex":[0.9957576,0.0005135821,0.00104395,0.001279925,0.0002105351,0.001194427],"domain_scores_gemma":[0.9966452,0.0002406694,0.00046875,0.001057862,0.001496926,0.00009057442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005322745,0.0002760325,0.001598714,0.00001790619,0.0001285137,0.00001540204,0.002628956,0.002167678,0.9728385,0.0003260662,0.0006783762,0.01879159],"study_design_scores_gemma":[0.001444264,0.0007523226,0.0160202,0.0001251751,0.0000356744,0.0009327793,0.002262657,0.0006937229,0.9651091,0.0001891023,0.01196536,0.0004696473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870478,0.001196187,0.0046521,0.0007383715,0.004689139,0.0004392899,0.00001666023,0.0001739941,0.001046446],"genre_scores_gemma":[0.9957705,0.0002764082,0.000500252,0.0006283371,0.0001224219,0.0000645768,0.0001118637,0.00004194855,0.00248365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01832195,"threshold_uncertainty_score":0.9997454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216375226847959,"score_gpt":0.2549406638547016,"score_spread":0.242776911586222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}