{"id":"W3165019140","doi":"10.3389/fragi.2021.649110","title":"Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McMaster University; NOSM University; Health Sciences North","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Aging; National Institutes of Health","keywords":"Medicine; Vaccination; Immunology; Serostatus; Peripheral blood mononuclear cell; Immune system; Influenza vaccine; Young adult; Virus; Internal medicine; Viral load; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003152375,0.001408538,0.0035037,0.0003969421,0.0004906202,0.001168236,0.0008553177,0.001987758,0.00478213],"category_scores_gemma":[0.002545977,0.0006767765,0.001978933,0.0003376485,0.001177449,0.001232724,0.0006566547,0.002418276,0.0006123284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006615092,"about_ca_system_score_gemma":0.001142194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004885026,"about_ca_topic_score_gemma":0.0007792907,"domain_scores_codex":[0.9982469,0.0009318202,0.0001568397,0.0003012941,0.00009693006,0.0002661298],"domain_scores_gemma":[0.9983377,0.0003975535,0.0003763887,0.0001659827,0.000109485,0.0006128169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9934609,0.002535885,0.0006109538,0.00009195127,0.0002801967,0.000008196739,0.00001361838,0.00005708371,0.0006322802,0.00002508611,0.00007634494,0.002207498],"study_design_scores_gemma":[0.8123364,0.1809148,0.004667358,0.00003932879,0.0006886648,0.00002458428,0.00003143134,0.0004393748,0.000345826,0.0001636061,0.0003337634,0.00001486567],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943296,0.001501792,0.0003325551,0.0003705542,0.0005372163,0.002137255,0.0002440299,0.00002721941,0.0005199019],"genre_scores_gemma":[0.9926425,0.0005491538,0.0008577983,0.0007652377,0.0004851259,0.003349671,0.0003149014,0.000008315358,0.001027381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00478213,"threshold_uncertainty_score":0.01667154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01938577760456574,"score_gpt":0.3272571079929798,"score_spread":0.3078713303884141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}