{"id":"W3165029898","doi":"10.1186/s13567-021-00952-8","title":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) moonlights as an adhesin in Mycoplasma hyorhinis adhesion to epithelial cells as well as a plasminogen receptor mediating extracellular matrix degradation","year":2021,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Jiangsu Agricultural Science and Technology Independent Innovation Fund; Six Talent Peaks Project in Jiangsu Province; Jiangsu Agricultural Science and Technology Innovation Fund; Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China; Jiangsu Academy of Agricultural Sciences","keywords":"Glyceraldehyde 3-phosphate dehydrogenase; Biology; Plasmin; Extracellular matrix; Fibronectin; Laminin; Molecular biology; Western blot; Bacterial adhesin; Microbiology; Cell biology; Biochemistry; Dehydrogenase; Enzyme; Virulence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002110546,0.0004256099,0.0005176912,0.0009208725,0.0008679677,0.0002325304,0.0006016557,0.0005660845,0.01598228],"category_scores_gemma":[0.00062771,0.0004314557,0.0002027053,0.001431848,0.0002394696,0.0004651839,0.0006863464,0.001144624,0.04002902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003945273,"about_ca_system_score_gemma":0.001114258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002952998,"about_ca_topic_score_gemma":0.0002332829,"domain_scores_codex":[0.9932512,0.0027426,0.0007664289,0.001266739,0.0004304555,0.001542588],"domain_scores_gemma":[0.9973647,0.0006797761,0.0001121048,0.0008926891,0.0004986727,0.0004520774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003190535,0.001045957,0.0002063521,0.0001063228,0.00007713497,0.00170772,0.00069867,0.00004904324,0.9872355,0.000410925,0.002368443,0.002903414],"study_design_scores_gemma":[0.001752517,0.003115935,0.00004703507,0.0001218056,0.00001605989,0.0008021425,0.0007760497,0.00009347251,0.8737684,0.0003197696,0.1187644,0.0004224138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931871,0.003045869,0.0000161031,0.0005296181,0.0006078162,0.001103742,0.0002064372,0.000110832,0.001192431],"genre_scores_gemma":[0.9685634,0.0009110816,0.0005533418,0.00009019311,0.0001670852,0.0002479978,0.0009400257,0.00009480477,0.02843205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.116396,"threshold_uncertainty_score":0.9998137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04876468979225942,"score_gpt":0.3615044802576817,"score_spread":0.3127397904654223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}