{"id":"W3165053782","doi":"10.1111/cmi.13371","title":"Candidalysin triggers epithelial cellular stresses that induce necrotic death","year":2021,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Dental and Craniofacial Research; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Directorate for Biological Sciences; King's College London; Deutsche Forschungsgemeinschaft; Wellcome Trust; National Institutes of Health; Pfizer","keywords":"Biology; Programmed cell death; Candida albicans; Apoptosis; Cell biology; Secretion; Necrosis; Cell; Mitochondrion; Cell damage; Microbiology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139439,0.0003357322,0.0002819505,0.0001859268,0.000206851,0.0003311087,0.0001392312,0.0004390807,0.001363744],"category_scores_gemma":[0.00009546733,0.0001024498,0.0002645608,0.0001634628,0.0002007288,0.0001937748,0.0003228071,0.0005549899,0.0003513128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805735,"about_ca_system_score_gemma":0.0002215505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002333703,"about_ca_topic_score_gemma":0.0003532707,"domain_scores_codex":[0.9997533,0.00003769876,0.00002154757,0.0000338471,0.00008512301,0.00006850233],"domain_scores_gemma":[0.999904,0.00001916789,0.00002079213,0.00001512188,0.00001950879,0.00002142068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001973022,0.00003229097,0.0001767285,0.00006833014,0.000004568048,0.0001615599,0.00001430746,0.00002252773,0.9982109,0.00005240773,0.00005263774,0.001006515],"study_design_scores_gemma":[0.00001778005,0.0003090818,0.006084,0.00001253109,0.000008305794,0.0005331828,0.00006827019,0.0003776253,0.9910319,0.00006344303,0.001490423,0.000003595649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909923,0.004086369,0.001626331,0.0001705771,0.00007284623,0.00004807963,0.0004318819,0.00007711189,0.00249451],"genre_scores_gemma":[0.9946806,0.00146079,0.001042633,0.0001399934,0.00001378626,0.00004368339,0.0004020106,0.000008569551,0.002207996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001363744,"threshold_uncertainty_score":0.004562199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02624022215826866,"score_gpt":0.2560677365170605,"score_spread":0.2298275143587918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}