{"id":"W3165053782","doi":"10.1111/cmi.13371","title":"Candidalysin triggers epithelial cellular stresses that induce necrotic death","year":2021,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Dental and Craniofacial Research; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Directorate for Biological Sciences; King's College London; Deutsche Forschungsgemeinschaft; Wellcome Trust; National Institutes of Health; Pfizer","keywords":"Biology; Programmed cell death; Candida albicans; Apoptosis; Cell biology; Secretion; Necrosis; Cell; Mitochondrion; Cell damage; Microbiology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002551409,0.0002919699,0.0006881105,0.00009114043,0.000149612,0.00003260489,0.0001629644,0.0003627285,0.001362221],"category_scores_gemma":[0.0001952912,0.0002525276,0.0003075472,0.0002563621,0.0002475177,0.00005212596,0.0000944894,0.0004141323,0.0002692911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001367844,"about_ca_system_score_gemma":0.0005265257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001122956,"about_ca_topic_score_gemma":0.0001100131,"domain_scores_codex":[0.9980004,0.0002368712,0.0003716631,0.0007010907,0.0001063825,0.0005835906],"domain_scores_gemma":[0.9986641,0.0001210939,0.0001142225,0.0007169581,0.0001891034,0.0001945279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162208,0.0002027988,0.04039827,0.0001155825,0.0001368784,0.0009560177,0.0001267241,0.000001882826,0.9566002,0.0001592769,0.0006232077,0.0005169477],"study_design_scores_gemma":[0.001290761,0.0001331005,0.004450737,0.0000740945,0.0002335433,0.0001349738,0.0003849571,0.000009428999,0.9667804,0.00009713369,0.02615288,0.0002579963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904078,0.005649334,0.001152075,0.0005402666,0.000456441,0.0002837308,0.00007767601,0.00006624476,0.001366415],"genre_scores_gemma":[0.9918372,0.0002026795,0.0004431639,0.0006179872,0.0001998948,0.000008348114,0.0006773994,0.00003511551,0.005978196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03594753,"threshold_uncertainty_score":0.9999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02624022215826866,"score_gpt":0.2560677365170605,"score_spread":0.2298275143587918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}