{"id":"W3165062616","doi":"10.4049/jimmunol.2001271","title":"TCR Affinity Controls the Dynamics but Not the Functional Specification of the Antimycobacterial CD4+ T Cell Response","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council","keywords":"Antimycobacterial; T-cell receptor; Dynamics (music); Chemistry; Functional response; T cell; Cd4 t cell; Computational biology; Biology; Cell biology; Immunology; Medicine; Immune system; Physics; Tuberculosis; Mycobacterium tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000233531,0.0002085104,0.0001894228,0.0002733063,0.0001105121,0.0005349403,0.0001909577,0.0003005221,0.001869827],"category_scores_gemma":[0.0003504966,0.0002854267,0.00008611415,0.0001486234,0.000156599,0.0002533181,0.0002366256,0.0005216112,0.0006291119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004072577,"about_ca_system_score_gemma":0.0001857772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000271493,"about_ca_topic_score_gemma":0.0006517671,"domain_scores_codex":[0.999627,0.00006946554,0.00002987499,0.00007364687,0.00007218688,0.000127717],"domain_scores_gemma":[0.9994707,0.0001365088,0.000122165,0.00006489057,0.00005841976,0.0001475066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004417815,0.000009696705,0.0002672345,0.000005597986,7.356522e-7,0.00000789073,0.00000318707,0.00003323655,0.9991513,0.00003469385,0.000007552147,0.0004346792],"study_design_scores_gemma":[0.00001908057,0.0002317833,0.02027068,0.000006092907,0.00001190233,0.0002175852,0.00004502371,0.003159789,0.9750029,0.00008757698,0.0009411651,0.000006515064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969963,0.0003838226,0.001429004,0.00002735865,0.000009684708,0.000006535121,0.00007694232,0.00004678378,0.001023672],"genre_scores_gemma":[0.9986035,0.0000957527,0.0006222497,0.00002225853,0.000006583036,0.000004618582,0.00005536839,0.00001812769,0.0005716328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869827,"threshold_uncertainty_score":0.006255209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426588092873241,"score_gpt":0.2081521506964698,"score_spread":0.1938862697677373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}