{"id":"W3165118996","doi":"10.1073/pnas.2104841118","title":"AP-1 is a temporally regulated dual gatekeeper of reprogramming to pluripotency","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Aging; Stanford Bio-X; Baxter International Foundation; National Science Foundation; Government of Canada; Canadian Institutes of Health Research; Li Ka Shing Foundation","keywords":"Reprogramming; Embryonic stem cell; Cell biology; Somatic cell; Biology; Stem cell; Repressor; Induced pluripotent stem cell; Gene; Transcription factor; Genetics; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002078831,0.0002677747,0.0002024224,0.0002334764,0.0002742794,0.0007483599,0.000369501,0.0003145426,0.00175799],"category_scores_gemma":[0.0002578306,0.0001818772,0.0001889442,0.0001652532,0.000412157,0.0003983388,0.000471092,0.001034002,0.0005999223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003943447,"about_ca_system_score_gemma":0.0002859017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001526011,"about_ca_topic_score_gemma":0.000234361,"domain_scores_codex":[0.9997728,0.00002417206,0.00001566181,0.00007363711,0.00008425966,0.00002952629],"domain_scores_gemma":[0.9998574,0.00002182832,0.00004361525,0.00002366894,0.00002048921,0.00003288594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006402823,0.000009813178,0.0001549839,0.00003128446,0.000003196704,0.00004851886,0.000007255906,0.00007536214,0.9946905,0.0009394162,0.00008232081,0.003893414],"study_design_scores_gemma":[0.00001649524,0.000123082,0.002219441,0.00001269439,0.00001714596,0.0006535458,0.00002560374,0.001394244,0.9815257,0.0008620509,0.01314293,0.000007053019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9034698,0.0255637,0.05247253,0.001897215,0.0005231213,0.00005736584,0.001010247,0.0008603124,0.01414572],"genre_scores_gemma":[0.9810514,0.003143623,0.007034585,0.0001530681,0.00007632839,0.00004084695,0.0004103259,0.00005142653,0.008038246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00175799,"threshold_uncertainty_score":0.005881011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366871731588704,"score_gpt":0.3162416070253246,"score_spread":0.2825728897094376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}