{"id":"W3165145678","doi":"10.2174/0929867328666210521213118","title":"Challenges and Perspectives in the Discovery of Dengue Virus EntryInhibitors","year":2021,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Agencia Nacional de Promoción Científica y Tecnológica; Consejo Nacional de Investigaciones Científicas y Técnicas","keywords":"Dengue virus; Dengue fever; Rational design; Drug discovery; Viral entry; Antiviral drug; Viral replication; Biology; Virology; Drug; Virus; Computational biology; Bioinformatics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008291336,0.0008450702,0.001318355,0.001817633,0.0003119819,0.001252872,0.001008463,0.001246976,0.004051809],"category_scores_gemma":[0.0008260148,0.0003900204,0.0006465474,0.001853492,0.0004674002,0.001855423,0.0008346046,0.002668628,0.002805898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005694244,"about_ca_system_score_gemma":0.0009693339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006081113,"about_ca_topic_score_gemma":0.001108505,"domain_scores_codex":[0.9997512,0.00004698433,0.00002508157,0.00003968313,0.0001064317,0.0000307215],"domain_scores_gemma":[0.9996731,0.0001762724,0.00002444313,0.00001138706,0.00008940438,0.00002539936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000088297,0.0001682165,0.0001677493,0.02755737,0.00009622694,0.0003745709,0.000147277,0.001669464,0.006141566,0.02726985,0.03620799,0.9001113],"study_design_scores_gemma":[0.00001861505,0.000144308,0.0002712702,0.002530381,0.00005946225,0.0006323053,0.00005775378,0.0003198722,0.001249446,0.004549771,0.9901454,0.00002144376],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003133443,0.9959463,0.0005639906,0.0005512954,0.0003227693,0.000008808842,0.00003228009,0.00001687371,0.002244277],"genre_scores_gemma":[0.001235776,0.9967476,0.0005993663,0.000322384,0.0001689894,0.00001225234,0.00004672276,0.000003995607,0.0008629105],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004051809,"threshold_uncertainty_score":0.01355463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1717858187373988,"score_gpt":0.4044189564055581,"score_spread":0.2326331376681593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}