{"id":"W3165178936","doi":"10.1016/j.celrep.2021.109163","title":"The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"H2020 European Research Council; Sahlgrenska Akademin; European Research Council; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Novo Nordisk Fonden; Diabetesförbundet; Pfizer; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; University of Toronto; Fondation Leducq; Novo Nordisk; Stiftelserna Wilhelm och Martina Lundgrens; Sanofi; Magnus Bergvalls Stiftelse; Hjärt-Lungfonden; Åke Wiberg Stiftelse","keywords":"Inflammation; Gut flora; Leptin; Endocrinology; Internal medicine; Leptin receptor; Biology; Hypothalamus; Receptor; Glucagon-like peptide-1; Diet-induced obese; Insulin resistance; Obesity; Immunology; Medicine; Type 2 diabetes; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005854913,0.0001637679,0.0001838211,0.00005339472,0.0002428961,0.0001688753,0.00006511258,0.0001034608,0.00001174099],"category_scores_gemma":[0.0002071544,0.0001408477,0.00005443722,0.0001737524,0.00008545644,0.0001787763,0.0001749202,0.0001530147,0.00001896893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006188432,"about_ca_system_score_gemma":0.00006633457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004953065,"about_ca_topic_score_gemma":0.0005459582,"domain_scores_codex":[0.9982879,0.0002127035,0.0004308979,0.0005540058,0.0002528958,0.0002615606],"domain_scores_gemma":[0.9988788,0.0002298625,0.0003017526,0.0004555912,0.00007081685,0.00006321361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002209803,0.00003176765,0.002783536,0.00002265226,0.000001902458,0.001311165,0.000199083,0.00004456602,0.9947761,0.00007039914,0.00001336444,0.0007233337],"study_design_scores_gemma":[0.0001759717,0.00002199851,0.04906128,0.00003193431,0.000007739392,0.0009204075,0.00004132169,0.0004535678,0.9462165,0.002156073,0.000761824,0.0001513378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978065,0.00007956536,0.0001528435,0.0005914979,0.0002741832,0.0002557329,0.000001633684,0.0000450849,0.0007929558],"genre_scores_gemma":[0.9953848,0.000130535,0.00009734737,0.0000875065,0.00005442524,0.000005576632,0.000006442199,0.00001708202,0.004216287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04855959,"threshold_uncertainty_score":0.5743604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081258304291718,"score_gpt":0.215481755012132,"score_spread":0.2046691719692148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}