{"id":"W3165229010","doi":"10.1002/anie.202105253","title":"Programmable RNA <i>N</i><sup>1</sup>‐Methyladenosine Demethylation by a Cas13d‐Directed Demethylase","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China","keywords":"Demethylase; Demethylation; N6-Methyladenosine; Chemistry; Biochemistry; Methyltransferase; Methylation; DNA; Epigenetics; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002357008,0.0003904218,0.0002029769,0.0001728667,0.0001706722,0.00036078,0.0004410917,0.0003563172,0.001452781],"category_scores_gemma":[0.0002144747,0.0002137424,0.0003200074,0.0001065917,0.0003298111,0.0001897142,0.0002846807,0.0006816309,0.0005978973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368009,"about_ca_system_score_gemma":0.0002405119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000581447,"about_ca_topic_score_gemma":0.0008797768,"domain_scores_codex":[0.999797,0.0000221215,0.00002318444,0.00007064096,0.0000563295,0.00003057746],"domain_scores_gemma":[0.9998195,0.00003906062,0.00006472493,0.0000394045,0.00001487355,0.00002246316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002757438,0.000009299561,0.000101635,0.0000235864,0.00000372632,0.00003259303,0.000006563532,0.0001194666,0.9974278,0.0002914778,0.00009316227,0.001863237],"study_design_scores_gemma":[0.000003607844,0.00002923855,0.0002454587,0.000001790677,0.000003486407,0.00008341092,0.000003095851,0.001084355,0.9959856,0.00002945051,0.00252601,0.000004489247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8107936,0.001614302,0.1702675,0.0003689782,0.000242417,0.0002808107,0.001674137,0.003880122,0.01087812],"genre_scores_gemma":[0.9214531,0.0006216022,0.06768642,0.0001487923,0.00002068927,0.0001121887,0.001068732,0.0002928818,0.008595642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452781,"threshold_uncertainty_score":0.004859984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131649083106389,"score_gpt":0.2594301680292223,"score_spread":0.2481136771981584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}