{"id":"W3165231313","doi":"10.1093/ecco-jcc/jjab093","title":"Long-Term Safety and Efficacy of Risankizumab Treatment in Patients with Crohn’s Disease: Results from the Phase 2 Open-Label Extension Study","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"AbbVie; Boehringer Ingelheim","keywords":"Medicine; Crohn's disease; Term (time); Open label; Crohn disease; Phase (matter); Disease; Internal medicine; Intensive care medicine; Pediatrics; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00494481,0.0006832259,0.001155134,0.0002087581,0.0002529202,0.0006597092,0.0003284133,0.0008062138,0.001447221],"category_scores_gemma":[0.002441089,0.000282069,0.001152826,0.0002106849,0.0005285708,0.0006229167,0.0002678516,0.002000813,0.0004291874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003738402,"about_ca_system_score_gemma":0.00070223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002123021,"about_ca_topic_score_gemma":0.0003109755,"domain_scores_codex":[0.9988558,0.0006955274,0.00008428021,0.0001131025,0.0001381794,0.0001131483],"domain_scores_gemma":[0.9971462,0.0007619943,0.000832141,0.0003250241,0.0002828321,0.0006518932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.685046,0.05220329,0.05538981,0.0007681642,0.002278212,0.0005757977,0.0008928958,0.001685078,0.04038944,0.0001569523,0.003340902,0.1572735],"study_design_scores_gemma":[0.281946,0.557503,0.1463086,0.00008352828,0.00117059,0.001122308,0.0001193879,0.001678879,0.005737873,0.0001485171,0.00411485,0.00006640796],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974124,0.001149222,0.0002732762,0.0001151214,0.00002912631,0.0002787283,0.0003326049,0.00002230491,0.0003872417],"genre_scores_gemma":[0.995738,0.0005875187,0.0007763524,0.0003529328,0.0001105417,0.0003779425,0.001594174,0.00001159972,0.0004508667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00494481,"threshold_uncertainty_score":0.026151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323032003824468,"score_gpt":0.2829221921877931,"score_spread":0.2696918721495484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}