{"id":"W3165234271","doi":"10.1111/bjh.17541","title":"Carfilzomib, dexamethasone and daratumumab in relapsed or refractory multiple myeloma: results of the phase III study CANDOR by prior lines of therapy","year":2021,"lang":"en","type":"letter","venue":"British Journal of Haematology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Amgen","keywords":"Lenalidomide; Daratumumab; Carfilzomib; Medicine; Multiple myeloma; Bortezomib; Oncology; Internal medicine; Dexamethasone; Proteasome inhibitor; Ixazomib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005792635,0.001192743,0.002749185,0.0003261602,0.000444798,0.001597029,0.0009630866,0.001368242,0.002486994],"category_scores_gemma":[0.002300063,0.0003303281,0.003116531,0.0005460693,0.0007069919,0.0008604385,0.0004630551,0.003581722,0.0006629403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001362405,"about_ca_system_score_gemma":0.001930181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002294593,"about_ca_topic_score_gemma":0.006118192,"domain_scores_codex":[0.9980603,0.0009761881,0.0001025604,0.000214017,0.000392278,0.0002546738],"domain_scores_gemma":[0.9977041,0.0005866645,0.0005081266,0.0001639501,0.0001926949,0.0008445713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6788296,0.02889602,0.01506865,0.001410123,0.005620261,0.0002317581,0.0002908565,0.002051153,0.009925625,0.0005750954,0.01626007,0.2408407],"study_design_scores_gemma":[0.5156301,0.3687619,0.07207263,0.0003673235,0.004559787,0.0006002278,0.0001148538,0.001761057,0.004687659,0.0004613347,0.03089058,0.00009257781],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8826253,0.0938559,0.001044299,0.004179902,0.0007849501,0.002036039,0.005593972,0.0001962175,0.009683406],"genre_scores_gemma":[0.9260169,0.04050409,0.002884143,0.005678634,0.001724755,0.001760509,0.0140568,0.0001258078,0.00724838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005792635,"threshold_uncertainty_score":0.03063476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03903658901030103,"score_gpt":0.3319339127795403,"score_spread":0.2928973237692392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}