{"id":"W3165241438","doi":"10.1002/art.41811","title":"Efficacy, Safety, and Pharmacodynamic Effects of the Bruton’s Tyrosine Kinase Inhibitor Fenebrutinib (GDC‐0853) in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double‐Blind, Placebo‐Controlled Trial","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Placebo; Medicine; Internal medicine; Adverse effect; Pharmacodynamics; Systemic lupus erythematosus; Clinical endpoint; Gastroenterology; Lupus erythematosus; Randomized controlled trial; Placebo-controlled study; Immunology; Pharmacokinetics; Antibody; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002274933,0.001122178,0.002149554,0.0002757874,0.0003351053,0.0007973254,0.0006453368,0.001376949,0.003938734],"category_scores_gemma":[0.001685714,0.0004260643,0.001158422,0.0002955052,0.000760564,0.00066934,0.0001749821,0.001614563,0.0005850666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005305126,"about_ca_system_score_gemma":0.0006607617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000340629,"about_ca_topic_score_gemma":0.0007520316,"domain_scores_codex":[0.9993419,0.00037458,0.00005543359,0.00009684733,0.00005798614,0.000073249],"domain_scores_gemma":[0.999056,0.0003077458,0.0002916195,0.00005254693,0.00006602122,0.0002259874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9424371,0.009067046,0.001513143,0.0009297359,0.00118642,0.00007445555,0.00005848505,0.0003617091,0.00798013,0.00006326166,0.001053928,0.03527458],"study_design_scores_gemma":[0.9157455,0.07723592,0.004462518,0.00004844313,0.0005781874,0.00009047356,0.00001461967,0.000293981,0.0008805083,0.00006190254,0.0005761192,0.00001179346],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862493,0.008853061,0.0004147293,0.0005459797,0.0001832074,0.001448165,0.0006522324,0.00007081331,0.001582585],"genre_scores_gemma":[0.9923427,0.003171508,0.0006950462,0.0006584783,0.0003113025,0.001345219,0.0006203327,0.0000132219,0.0008421853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003938734,"threshold_uncertainty_score":0.01317638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244133318529877,"score_gpt":0.2975287310630316,"score_spread":0.2850873978777329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}