{"id":"W3165241438","doi":"10.1002/art.41811","title":"Efficacy, Safety, and Pharmacodynamic Effects of the Bruton’s Tyrosine Kinase Inhibitor Fenebrutinib (GDC‐0853) in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double‐Blind, Placebo‐Controlled Trial","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Placebo; Medicine; Internal medicine; Adverse effect; Pharmacodynamics; Systemic lupus erythematosus; Clinical endpoint; Gastroenterology; Lupus erythematosus; Randomized controlled trial; Placebo-controlled study; Immunology; Pharmacokinetics; Antibody; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003327515,0.0005694365,0.005211483,0.000577313,0.0001846202,0.00002547145,0.0003691024,0.0004567601,0.00005166678],"category_scores_gemma":[0.005903739,0.0004189309,0.0007192593,0.0009313509,0.001011504,0.000118124,0.0005249912,0.0006623329,0.00001114733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001674325,"about_ca_system_score_gemma":0.001005667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003205797,"about_ca_topic_score_gemma":0.0003107477,"domain_scores_codex":[0.9911989,0.002405544,0.003713645,0.000933115,0.0008975999,0.0008512021],"domain_scores_gemma":[0.990713,0.006087401,0.001285945,0.001123422,0.0005048652,0.0002853411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9650456,0.002352933,0.00172374,0.002971147,0.0007303364,0.0006045566,0.003002388,0.00001095729,0.02083028,0.0009055093,0.0002655791,0.00155691],"study_design_scores_gemma":[0.911981,0.001073032,0.000007006524,0.01134463,0.0003151675,0.05773009,0.0005214394,0.0008304863,0.01578075,0.00006454992,0.00007382619,0.000278002],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532149,0.02949882,0.00003553543,0.0009545464,0.00217119,0.01347868,0.00005455034,0.00006708634,0.0005247109],"genre_scores_gemma":[0.9896322,0.008410489,0.0000752808,0.00004017885,0.0000787852,0.0009516241,0.000057218,0.00008058043,0.0006736101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05712553,"threshold_uncertainty_score":0.9998263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244133318529877,"score_gpt":0.2975287310630316,"score_spread":0.2850873978777329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}