{"id":"W3165249197","doi":"10.1016/j.jhep.2021.04.055","title":"An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs","year":2021,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Toronto Liver Centre; University of Toronto","funders":"Japan Society for the Promotion of Science; Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; American Medical Association Foundation; National Institutes of Health; University of Bristol; Canadian Institutes of Health Research; Ministero dell’Istruzione, dell’Università e della Ricerca; National Institute for Health and Care Research; Medical Research Council; Cancer Prevention and Research Institute of Texas; Ontario Research Foundation; Japan Agency for Medical Research and Development; University of Essex; Wellcome Trust","keywords":"Biology; Genome-wide association study; Candidate gene; Genetics; Genome; Bioinformatics; Gene; Internal medicine; Medicine; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007844691,0.002187596,0.004918143,0.004136533,0.001129841,0.00249552,0.001293687,0.001716753,0.004071669],"category_scores_gemma":[0.01109737,0.001017784,0.02470637,0.006391651,0.0004760643,0.000698249,0.001599582,0.002016383,0.0003336622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001170976,"about_ca_system_score_gemma":0.001651848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01377711,"about_ca_topic_score_gemma":0.01484291,"domain_scores_codex":[0.99291,0.003361555,0.0007575515,0.001673432,0.0007296433,0.0005679165],"domain_scores_gemma":[0.9924915,0.004308167,0.0009469349,0.001272487,0.0006200232,0.0003608605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.009769861,0.00005964893,0.3447841,0.004431528,0.6206734,0.0008505717,0.0001045743,0.002848079,0.001180655,0.0003430308,0.003293777,0.01166083],"study_design_scores_gemma":[0.001302194,0.00043929,0.233867,0.0006062931,0.752902,0.0008574518,0.0001426858,0.005229769,0.0005690607,0.0008664718,0.003155218,0.00006259933],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5776382,0.3912877,0.01000435,0.002807798,0.001034613,0.0002529172,0.01252511,0.0004839801,0.003965266],"genre_scores_gemma":[0.9789886,0.01510347,0.001904781,0.0004893682,0.000206262,0.0001366693,0.002498191,0.00008018247,0.0005924411],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01377711,"threshold_uncertainty_score":0.04148716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06771093754336596,"score_gpt":0.352518170676242,"score_spread":0.284807233132876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}