{"id":"W3165251326","doi":"10.1101/2021.05.22.445239","title":"The Telomere Length Landscape of Prostate Cancer","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Prostate Cancer Canada; Government of Ontario; Canadian Institutes of Health Research; Instituto Tecnológico de Costa Rica; National Institutes of Health; Ontario Genomics; Genome Canada; Government of Canada; Ontario Institute for Cancer Research; Ontario Genomics Institute; Movember Foundation","keywords":"Telomere; Prostate cancer; Genome instability; Biology; Transcriptome; Cancer; Genomics; Proteomics; Prostate; Cancer research; Telomerase; Indel; Gene; Computational biology; Genetics; Single-nucleotide polymorphism; Genome; Genotype; DNA damage; DNA; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915209,0.0001607931,0.0002970163,0.0007373544,0.000226103,0.000984847,0.000123121,0.0001963367,0.001270105],"category_scores_gemma":[0.0004145263,0.0001071681,0.0002248587,0.001145236,0.0001779218,0.0002728051,0.0004112702,0.0003641197,0.0002520077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003624805,"about_ca_system_score_gemma":0.0002062059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006785186,"about_ca_topic_score_gemma":0.0006926783,"domain_scores_codex":[0.9998564,0.00001885603,0.000006586758,0.0000553668,0.00004050184,0.00002231351],"domain_scores_gemma":[0.9997714,0.00005028364,0.00009029304,0.00002005822,0.00003604717,0.00003197168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008299597,0.00005320439,0.1899333,0.0006162616,0.0004056352,0.0004892594,0.0004259826,0.003945251,0.7221845,0.002749035,0.002948297,0.07541941],"study_design_scores_gemma":[0.0000207572,0.0003330381,0.9019691,0.0000834033,0.0002355372,0.001674781,0.0005214814,0.006720001,0.05900786,0.008117779,0.02124722,0.00006912062],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718527,0.01557075,0.004028119,0.0008063117,0.00003446553,0.00001006415,0.005189532,0.0001735393,0.002334605],"genre_scores_gemma":[0.9937163,0.002095672,0.001213836,0.0001747927,0.00003843318,0.000009446737,0.002028807,0.00002200132,0.0007007958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270105,"threshold_uncertainty_score":0.004248977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303900362027238,"score_gpt":0.238512801178612,"score_spread":0.2254737975583396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}