{"id":"W3165280449","doi":"10.1039/d1dt00412c","title":"Role of π-conjugation on the coordination behaviour, substitution kinetics, DNA/BSA interactions, and <i>in vitro</i> cytotoxicity of carboxamide palladium(<scp>ii</scp>) complexes","year":2021,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bell (Canada)","funders":"University of the Western Cape; Department of Science and Technology, Republic of South Africa; Inyuvesi Yakwazulu-Natali; National Research Foundation","keywords":"Palladium; Chemistry; Kinetics; Cytotoxicity; In vitro; Substitution (logic); DNA; Carboxamide; Stereochemistry; Medicinal chemistry; Combinatorial chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002199093,0.0001389598,0.0003166994,0.0001515566,0.0001393797,0.00001481231,0.00005777646,0.00006596281,0.00005132467],"category_scores_gemma":[0.000154453,0.0001106353,0.0001077045,0.0002637641,0.0001548673,0.0001033328,0.000008110279,0.0002129919,0.000002056706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005997107,"about_ca_system_score_gemma":0.00005509945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000296958,"about_ca_topic_score_gemma":0.0004626039,"domain_scores_codex":[0.9988064,0.0001655658,0.0004395969,0.0002109009,0.0002381531,0.0001394119],"domain_scores_gemma":[0.9989876,0.0003464782,0.0001542011,0.0002485955,0.0002104668,0.00005263808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009830241,0.0004345703,0.0009890968,0.00007173809,0.00004331863,0.000001142829,0.000527669,0.0001018491,0.9960702,0.000751311,0.00001875826,0.0008920262],"study_design_scores_gemma":[0.0004213412,0.0001559219,0.05147177,0.0001390106,0.0001395251,0.00002366119,0.000890166,0.0009568079,0.9447944,0.0001713648,0.0007884221,0.00004758851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960161,0.000438413,0.00119953,0.0006649711,0.00009722967,0.0003349665,0.0001121904,0.00002061181,0.001115913],"genre_scores_gemma":[0.9990405,0.0001388249,0.0003209844,0.00008648001,0.0000257966,0.00003586808,0.00008009122,0.00001330486,0.0002581137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0512758,"threshold_uncertainty_score":0.4511576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02600516941710687,"score_gpt":0.2490043773055839,"score_spread":0.222999207888477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}