{"id":"W3165322373","doi":"10.1016/j.isci.2021.102574","title":"A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Retinal; Cell biology; Biology; Progenitor cell; Retina; Stem cell; Cellular differentiation; Neuroscience; Genetics; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006795352,0.00007012967,0.00007135455,0.0000191516,0.00004291618,0.00001946668,0.0001353177,0.00003920768,0.0001175355],"category_scores_gemma":[0.00003037972,0.000065,0.00004151217,0.0001855918,0.0000434344,0.000003042639,0.00008163837,0.00002335933,0.00001372001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004781929,"about_ca_system_score_gemma":0.0001248632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001190167,"about_ca_topic_score_gemma":0.00005019454,"domain_scores_codex":[0.9992891,0.00002341221,0.0001275498,0.0002464424,0.000174818,0.0001386962],"domain_scores_gemma":[0.9996471,0.000007511583,0.00005061886,0.0001480714,0.00009259357,0.00005406455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003496538,0.00003878404,0.04489809,0.00001420475,0.000003054446,0.000001361199,0.0001021753,0.00001105013,0.9496942,0.00004067186,0.003567798,0.001593687],"study_design_scores_gemma":[0.0001936168,0.0000907324,0.06188723,0.00001115742,0.000004187715,0.000002281292,0.0002159045,0.00005064875,0.9330279,0.00003891205,0.004378278,0.00009912933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952821,0.0002743221,0.002215122,0.0002190126,0.00007638123,0.00005305281,0.00001266955,0.000003442817,0.001863966],"genre_scores_gemma":[0.9963431,0.00003131106,0.001779857,0.0002911672,0.00001624053,0.000004146813,0.00004143286,0.00000406645,0.001488704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01698914,"threshold_uncertainty_score":0.2650623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254947982549718,"score_gpt":0.2339939679196543,"score_spread":0.2214444880941572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}