{"id":"W3165322373","doi":"10.1016/j.isci.2021.102574","title":"A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Retinal; Cell biology; Biology; Progenitor cell; Retina; Stem cell; Cellular differentiation; Neuroscience; Genetics; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001401958,0.0002038821,0.0004205798,0.000479699,0.000198515,0.0005003845,0.0001555826,0.0002068978,0.001256074],"category_scores_gemma":[0.0003348434,0.0001236313,0.0001924191,0.0002637941,0.0001682647,0.0001365091,0.0002655628,0.0002640779,0.0006127126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096329,"about_ca_system_score_gemma":0.0001902114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008304259,"about_ca_topic_score_gemma":0.0009980316,"domain_scores_codex":[0.9997597,0.00002068443,0.00002868749,0.00006016813,0.00009765768,0.0000330427],"domain_scores_gemma":[0.9995942,0.0001002493,0.00007331411,0.0000685267,0.0000825117,0.00008129091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009770519,0.00002004177,0.004043936,0.0000213088,0.000007012522,0.0001733035,0.00004756179,0.0001033367,0.9895238,0.000254945,0.00009649913,0.0056107],"study_design_scores_gemma":[0.00001752154,0.0003966602,0.07104729,0.00001287903,0.00004946641,0.002829591,0.0001097047,0.002891708,0.9145992,0.0002673096,0.007765044,0.00001348719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911534,0.0009513641,0.003569581,0.00004534235,0.00001293582,0.00003278641,0.0003996508,0.0001629751,0.003671957],"genre_scores_gemma":[0.993782,0.0003248807,0.002044832,0.00005737001,0.00001717061,0.00004310458,0.0009606616,0.00005662614,0.002713445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256074,"threshold_uncertainty_score":0.004202008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254947982549718,"score_gpt":0.2339939679196543,"score_spread":0.2214444880941572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}