{"id":"W3165341576","doi":"10.1002/anie.202105800","title":"Enantio‐ and Diastereodivergent Sequential Catalysis Featuring Two Transition‐Metal‐Catalyzed Asymmetric Reactions","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Euskal Herriko Unibertsitatea; Eusko Jaurlaritza","keywords":"Stereoselectivity; Stereocenter; Enantioselective synthesis; Catalysis; Chemistry; Tsuji–Trost reaction; Combinatorial chemistry; Enol; Alkylation; Enantiomer; Transition metal; Allylic rearrangement; Cascade reaction; Conjugate; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000324106,0.0007024133,0.0003528721,0.0002386757,0.0001725747,0.000725343,0.000694796,0.0004417656,0.001475632],"category_scores_gemma":[0.0001935128,0.0002801955,0.0002615347,0.000204488,0.0002752655,0.0006366698,0.0007684613,0.0007615116,0.001124335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863617,"about_ca_system_score_gemma":0.0004583714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002555017,"about_ca_topic_score_gemma":0.0006369287,"domain_scores_codex":[0.9996603,0.0000241707,0.00003125273,0.00009705462,0.00007878153,0.0001085348],"domain_scores_gemma":[0.9999256,0.000009492702,0.00001592334,0.00002235058,0.00000958851,0.00001703959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002090011,0.0001841047,0.0003770198,0.0001306487,0.00002595912,0.0003346983,0.00004439518,0.0004530034,0.9669263,0.003722085,0.0003464834,0.02724631],"study_design_scores_gemma":[0.00003244625,0.000166557,0.0002856476,0.000004394898,0.00001927567,0.0004471656,0.00001313387,0.001739292,0.9916953,0.0002384613,0.005347586,0.0000107848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8858837,0.002583634,0.07321636,0.0003318477,0.0003962659,0.0002707091,0.0003222642,0.0006866104,0.03630865],"genre_scores_gemma":[0.9718795,0.0006097979,0.0226179,0.00006552663,0.00003401186,0.00005190455,0.0001874251,0.00003474217,0.004519148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475632,"threshold_uncertainty_score":0.004936457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657278580593703,"score_gpt":0.250377793744317,"score_spread":0.2338050079383799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}