{"id":"W3165395408","doi":"10.1016/j.jhep.2021.01.024","title":"The search for disease-modifying agents in decompensated cirrhosis: From drug repurposing to drug discovery","year":2021,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Università di Bologna; European Commission; National Institute for Health and Care Research","keywords":"Drug repositioning; Drug; Drug discovery; Medicine; Repurposing; Disease; Cirrhosis; Intensive care medicine; Internal medicine; Pharmacology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01034236,0.0009004222,0.0034093,0.002539299,0.0007185452,0.004806326,0.001632584,0.004919388,0.008514503],"category_scores_gemma":[0.00957043,0.0005361851,0.001539978,0.002497831,0.00353513,0.009547091,0.002647526,0.007646973,0.004134359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002518013,"about_ca_system_score_gemma":0.00460413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005143417,"about_ca_topic_score_gemma":0.001201027,"domain_scores_codex":[0.9969116,0.001272426,0.0002623733,0.0004355896,0.0008276119,0.000290406],"domain_scores_gemma":[0.9799225,0.01271999,0.002079004,0.000746707,0.002771878,0.001759944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001083557,0.0005943825,0.001785818,0.0103634,0.0003572362,0.0007846215,0.0003432457,0.0009731273,0.008784307,0.04769584,0.07339392,0.8538405],"study_design_scores_gemma":[0.001100429,0.003075391,0.00335014,0.007358583,0.0005719443,0.001912362,0.0008367687,0.001999909,0.004506026,0.1072883,0.8678209,0.00017934],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004849151,0.8986508,0.004107807,0.08523089,0.002363227,0.0000730563,0.0001936047,0.0001417989,0.004389615],"genre_scores_gemma":[0.04352988,0.8764861,0.01123,0.05449496,0.008640988,0.0001981287,0.0005275431,0.0001069859,0.004785535],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01034236,"threshold_uncertainty_score":0.05469626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09886415946076886,"score_gpt":0.412644834594498,"score_spread":0.3137806751337291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}