{"id":"W3165423028","doi":"10.1371/journal.ppat.1009628","title":"The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Prion Research Institute; Novartis Institutes for BioMedical Research; University of California, San Francisco; Canadian Food Inspection Agency; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Bovine spongiform encephalopathy; Fibril; Immunogold labelling; Scrapie; Ultrastructure; Proteinase K; Chemistry; Monoclonal antibody; Epitope; Amyloid (mycology); Negative stain; Electron microscope; Prion protein; Biology; Biophysics; Molecular biology; Virology; Biochemistry; Antibody; Anatomy; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006149,0.0001496844,0.0001452852,0.00002069239,0.0001575817,0.00002702035,0.0001712177,0.00011744,0.00004258569],"category_scores_gemma":[0.000271343,0.0001210866,0.0001525861,0.0001661154,0.0001164959,0.000004603854,0.000109332,0.00009932176,0.000003094736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008670251,"about_ca_system_score_gemma":0.0002620594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002683614,"about_ca_topic_score_gemma":0.00001446752,"domain_scores_codex":[0.9990093,0.00007513143,0.0002201558,0.0002754985,0.0001690781,0.0002507989],"domain_scores_gemma":[0.999054,0.00002394558,0.00009612015,0.000452587,0.0002689158,0.0001044469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004070365,0.00005872138,0.001903444,0.00002207876,0.0000967999,0.00003626031,0.0000517231,0.0004544551,0.9919403,0.001306847,0.00003400669,0.004054681],"study_design_scores_gemma":[0.0004505782,0.0002614969,0.00184712,0.00003803711,0.0001037069,0.0001131229,0.0002268243,0.0005389133,0.990894,0.00240459,0.002845349,0.0002763013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878142,0.008161368,0.002247041,0.00008122353,0.0001265746,0.0001828135,0.0001687984,0.00001661735,0.001201403],"genre_scores_gemma":[0.9962053,0.002680017,0.0006925504,0.0001213361,0.00008378356,0.00001373758,0.0001248699,0.00002148344,0.00005691253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008391148,"threshold_uncertainty_score":0.4937767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008786887255566544,"score_gpt":0.2236697607663038,"score_spread":0.2148828735107373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}