{"id":"W3165423028","doi":"10.1371/journal.ppat.1009628","title":"The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Prion Research Institute; Novartis Institutes for BioMedical Research; University of California, San Francisco; Canadian Food Inspection Agency; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Bovine spongiform encephalopathy; Fibril; Immunogold labelling; Scrapie; Ultrastructure; Proteinase K; Chemistry; Monoclonal antibody; Epitope; Amyloid (mycology); Negative stain; Electron microscope; Prion protein; Biology; Biophysics; Molecular biology; Virology; Biochemistry; Antibody; Anatomy; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003116929,0.0005163749,0.0003238379,0.0003775256,0.0003161429,0.0006582757,0.0006228431,0.0005720603,0.0003991149],"category_scores_gemma":[0.0004417072,0.0003351229,0.000286025,0.0002405977,0.0006927209,0.001205313,0.0003583579,0.000410558,0.0001876118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004867511,"about_ca_system_score_gemma":0.0001935875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001259241,"about_ca_topic_score_gemma":0.001031089,"domain_scores_codex":[0.9998876,0.00002636427,0.000006908348,0.00002861018,0.00003191787,0.00001858297],"domain_scores_gemma":[0.9997963,0.00004933939,0.00006921582,0.00002886812,0.00002418409,0.00003201522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002475157,0.0001481128,0.00881739,0.0003741869,0.00005977047,0.0007039447,0.0004832238,0.03533484,0.9122145,0.03274796,0.0003369792,0.008531502],"study_design_scores_gemma":[0.0001023311,0.001232047,0.08551238,0.0001749802,0.0002517595,0.002654144,0.0009267252,0.6344619,0.1338207,0.1239846,0.01669894,0.0001795836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675198,0.005653312,0.02285353,0.0002801221,0.00002608886,0.00001744162,0.000117483,0.0000598352,0.003472352],"genre_scores_gemma":[0.9902273,0.003877356,0.005167859,0.00004613212,0.00002310211,0.00002021272,0.0002501218,0.00001399825,0.0003738336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259241,"threshold_uncertainty_score":0.003531635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008786887255566544,"score_gpt":0.2236697607663038,"score_spread":0.2148828735107373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}