{"id":"W3165430172","doi":"10.1002/ana.26137","title":"Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis","year":2021,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"Biogen; Celgene; Sanofi; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Medicine; Multiple sclerosis; Intrathecal; Magnetic resonance imaging; Internal medicine; Gastroenterology; Biomarker; Cerebrospinal fluid; Immunoglobulin G; Antibody; Clinically isolated syndrome; Immunology; Surgery; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000509364,0.0003197744,0.0003346175,0.0004081106,0.0001823527,0.0003912033,0.000169963,0.0003582503,0.00120811],"category_scores_gemma":[0.002146887,0.0001154685,0.000244189,0.0004036574,0.0002180441,0.0003093324,0.000268104,0.0004076063,0.0001548172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653881,"about_ca_system_score_gemma":0.0001559696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008377662,"about_ca_topic_score_gemma":0.0006743345,"domain_scores_codex":[0.9997603,0.00007186684,0.0000333616,0.00006285655,0.00004178839,0.00002969541],"domain_scores_gemma":[0.9978511,0.0004522551,0.001333072,0.0001036701,0.00009019664,0.0001697157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006679691,0.00003903359,0.9948973,0.00001657046,0.00007932488,0.00005162487,0.00002753072,0.0000871259,0.002184775,0.00000785353,0.0000216014,0.001919313],"study_design_scores_gemma":[0.000009124736,0.0002237692,0.9988575,0.00000325198,0.00003071664,0.0002869012,0.00002392772,0.00020474,0.0002902064,0.00001364773,0.0000543119,0.000001875308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994685,0.0002564162,0.00008383411,0.0000135549,0.000001528334,0.00000192432,0.00006136078,0.000004216934,0.0001086206],"genre_scores_gemma":[0.999732,0.00004982665,0.0000824191,0.000006018199,0.000006305936,0.000002161572,0.00007089667,9.847167e-7,0.00004941372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120811,"threshold_uncertainty_score":0.004041493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2487880139880915,"score_gpt":0.3734927370360456,"score_spread":0.1247047230479541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}