{"id":"W3165443810","doi":"10.1126/scisignal.aaz3578","title":"Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence","year":2021,"lang":"en","type":"article","venue":"Science Signaling","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development; Takeda Canada; Takeda Science Foundation","keywords":"Senescence; Carcinogenesis; Cellular senescence; microRNA; Cell biology; Biology; Polarity (international relations); Cancer research; Cell growth; Cell; Phenotype; Cancer; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006172626,0.0001626534,0.0001668929,0.00007603637,0.0002447751,0.00005600079,0.0002381298,0.00009836933,0.00002583605],"category_scores_gemma":[0.0003073299,0.0001540542,0.00008138668,0.0006003477,0.0003515491,0.00001566491,0.0001307634,0.0001191382,0.00001062868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002051255,"about_ca_system_score_gemma":0.0005246596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001275152,"about_ca_topic_score_gemma":0.000002082568,"domain_scores_codex":[0.9981894,0.00009062693,0.0003057996,0.0005939099,0.000420671,0.0003995392],"domain_scores_gemma":[0.9989812,0.00002106623,0.0001850538,0.000307112,0.0003526057,0.0001529537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001527215,0.00007760455,0.0007022874,0.00002435158,0.000005951299,0.00001859244,0.0001313344,0.00002001393,0.9982773,0.00001031522,0.00002599237,0.0006909788],"study_design_scores_gemma":[0.0002790493,0.0001377137,0.00004142649,0.0001635275,0.000009091381,0.0000129138,0.0003741304,0.0002161978,0.9982108,0.00003314982,0.0003240032,0.0001979658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940715,0.0009251336,0.004458838,0.00005894192,0.0001844964,0.0001164555,0.00002192717,0.00002203877,0.0001406381],"genre_scores_gemma":[0.9981147,0.00002099675,0.001453113,0.0001080118,0.000100916,0.000008178425,0.0001256938,0.00001579059,0.0000525848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004043184,"threshold_uncertainty_score":0.628215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040324665202147,"score_gpt":0.2515269770843933,"score_spread":0.2411237304323718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}