{"id":"W3165452661","doi":"10.15252/msb.202010138","title":"Natural variants suppress mutations in hundreds of essential genes","year":2021,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Fondation pour la Recherche Médicale; Eesti Teadusagentuur; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Genetics; Allele; Gene; Genetic architecture; Context (archaeology); Mutant; Phenotype; Genetic variation; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541333,0.0001285279,0.0002266566,0.00009063337,0.00003119423,0.00001644298,0.0002099528,0.000210039,0.00001785441],"category_scores_gemma":[0.0000994873,0.0001282917,0.00009080262,0.0002067223,0.0001150052,0.000002025153,0.0001933963,0.0001053125,0.000007678287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001049793,"about_ca_system_score_gemma":0.0001621632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001258196,"about_ca_topic_score_gemma":0.00008681108,"domain_scores_codex":[0.9985505,0.0003444842,0.0003118929,0.0003810255,0.0001164812,0.0002955957],"domain_scores_gemma":[0.9992763,0.00001518931,0.00006705897,0.0003626312,0.0002212861,0.00005748254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003159457,0.00007029672,0.003068178,0.00005394114,0.00007163094,0.00006634748,0.00002482242,0.0004841876,0.9949486,0.0006870363,0.00005278761,0.0004406115],"study_design_scores_gemma":[0.0005634815,0.0001155659,0.002636709,0.00002033492,0.00001097183,0.00009354651,0.00008958909,0.0006218935,0.9933202,0.00006154094,0.002310191,0.0001559853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982098,0.01381225,0.002492976,0.00007032238,0.0005851769,0.0001662025,0.00006195036,0.00000519872,0.0007078703],"genre_scores_gemma":[0.9984826,0.0001311655,0.0002817226,0.00003002033,0.0001052405,0.00003268671,0.0004768865,0.0000174141,0.0004422365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01638458,"threshold_uncertainty_score":0.5231585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008176868705119585,"score_gpt":0.2808024275880087,"score_spread":0.2726255588828891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}