{"id":"W3165452661","doi":"10.15252/msb.202010138","title":"Natural variants suppress mutations in hundreds of essential genes","year":2021,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Fondation pour la Recherche Médicale; Eesti Teadusagentuur; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Genetics; Allele; Gene; Genetic architecture; Context (archaeology); Mutant; Phenotype; Genetic variation; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000303508,0.0004565106,0.0003181694,0.0005588218,0.0001760639,0.000267429,0.0003895146,0.0003245918,0.001990642],"category_scores_gemma":[0.0004404437,0.0002145011,0.0002881984,0.0003529228,0.0003300209,0.0001551668,0.0006005853,0.0004600585,0.0004052381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002547656,"about_ca_system_score_gemma":0.0001767339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003177392,"about_ca_topic_score_gemma":0.001172587,"domain_scores_codex":[0.9995989,0.00005135145,0.00004981479,0.0001309517,0.0001288942,0.00004003647],"domain_scores_gemma":[0.9994808,0.0001436841,0.0001653431,0.00009361016,0.00003518583,0.00008147851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005051067,0.00002193477,0.001384934,0.00001956655,0.00001791024,0.00005453366,0.000008516744,0.00006064483,0.9971201,0.00008136502,0.00001457365,0.001165411],"study_design_scores_gemma":[0.00005329667,0.0007733885,0.09899715,0.00001942314,0.0001461077,0.002441257,0.00009254849,0.002387757,0.890973,0.0003306693,0.003755331,0.00003001013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947732,0.0003662699,0.003527714,0.00002863411,0.0000177952,0.00002468532,0.0003792447,0.0001163771,0.0007660792],"genre_scores_gemma":[0.9961132,0.000183018,0.002398431,0.00004194586,0.000007059333,0.00002714535,0.0005615691,0.0000556187,0.000612139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990642,"threshold_uncertainty_score":0.006659389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008176868705119585,"score_gpt":0.2808024275880087,"score_spread":0.2726255588828891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}