{"id":"W3165483273","doi":"10.3389/fcell.2021.660316","title":"Activin A as a Novel Chemokine Induces Migration of L929 Fibroblasts by ERK Signaling in Microfluidic Devices","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Defense Basic Scientific Research Program of China; National Natural Science Foundation of China; Department of Finance of Jilin Province; People's Government of Jilin Province; National Key Research and Development Program of China; Natural Science Foundation of Jilin Province","keywords":"Cell biology; Fibroblast; Chemokine; MAPK/ERK pathway; Fibrosis; Cytokine; Chemotaxis; Wound healing; Chemistry; TGF beta signaling pathway; Interleukin 8; Cell migration; Activin type 2 receptors; Transforming growth factor; Signal transduction; Cell culture; Cancer research; Immunology; Biology; Cell; Inflammation; Internal medicine; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044166,0.000155978,0.0002199272,0.00009125705,0.00003112452,0.00001031521,0.000105242,0.000203702,0.00001718072],"category_scores_gemma":[0.00005123439,0.0001608223,0.00003134615,0.0001525019,0.00009840811,0.000007106154,0.0001170193,0.00008041909,0.000001348443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003132801,"about_ca_system_score_gemma":0.0002371179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007756842,"about_ca_topic_score_gemma":0.00008208399,"domain_scores_codex":[0.9989985,0.0000547115,0.0002968093,0.0003839075,0.00005505241,0.000211014],"domain_scores_gemma":[0.9997286,0.00002003524,0.00008953848,0.0000815091,0.00003088388,0.00004946887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001012118,0.0001574077,0.09153869,0.00004571602,0.00002673055,0.000003397268,0.0001971498,0.000002263336,0.9046172,0.000001385128,0.002291621,0.001017248],"study_design_scores_gemma":[0.0007898053,0.00007859163,0.005377573,0.00005436954,0.00000558801,0.000009667049,0.0007894437,0.000007102877,0.9852063,0.00003901923,0.007457382,0.0001851315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985985,0.01281771,0.0006918722,0.00003420973,0.0001331441,0.00009445973,0.00003035371,0.000004559432,0.0002086822],"genre_scores_gemma":[0.9880092,0.000476671,0.01071548,0.0001651671,0.00002713177,0.00001730894,0.0004514328,0.00001156123,0.0001260247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08616111,"threshold_uncertainty_score":0.6558141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006044466239786913,"score_gpt":0.2176009525586029,"score_spread":0.211556486318816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}