{"id":"W3165509857","doi":"10.1016/j.molimm.2021.05.008","title":"Identification of imidazoquinoline derivative (IQD) interacting sites of porcine TLR8 and the underlying species specificity","year":2021,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Key Research and Development Program of China; Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Innate immune system; Receptor; Biology; Binding site; Intracellular; Mutant; Cell biology; Immune system; Agonist; Signal transducing adaptor protein; Chemistry; Signal transduction; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309841,0.000195241,0.0001854933,0.0001191134,0.0001542129,0.0001293565,0.0004358935,0.0002911052,0.002765004],"category_scores_gemma":[0.0001589848,0.00009507859,0.0002476372,0.00007731984,0.000172411,0.0001602464,0.0001816596,0.0003106733,0.0004668109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455584,"about_ca_system_score_gemma":0.0001126941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005826697,"about_ca_topic_score_gemma":0.0006673552,"domain_scores_codex":[0.9999025,0.00001564256,0.000004389717,0.00002911914,0.00002003932,0.00002834899],"domain_scores_gemma":[0.9999391,0.00001076719,0.0000204819,0.000006314825,0.00001242603,0.00001098365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002022042,0.00001743021,0.0007053343,0.00004599813,0.000007086311,0.0001467874,0.00002144962,0.000166648,0.9966336,0.0002798293,0.0000785287,0.001695163],"study_design_scores_gemma":[0.00005929061,0.0004515008,0.01497893,0.00002550549,0.00003791137,0.001622777,0.0001634195,0.00580049,0.9681621,0.0006267365,0.00804627,0.00002519632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856516,0.002045547,0.008804092,0.0001704842,0.00003458332,0.0000367774,0.0003192749,0.00006182826,0.002875901],"genre_scores_gemma":[0.994867,0.0003197024,0.003093069,0.000095043,0.000005852299,0.00001686579,0.0003770081,0.00000637043,0.001219236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002765004,"threshold_uncertainty_score":0.009249866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837893994297253,"score_gpt":0.2562519109467827,"score_spread":0.2378729710038102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}