{"id":"W3165520564","doi":"10.1016/j.mcpro.2021.100101","title":"Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis","year":2021,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Rehabilitation Institute; Western University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Western Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; Krembil Foundation; Canada Foundation for Innovation; Ontario Research Foundation; Natural Sciences and Engineering Research Council of Canada; International Business Machines Corporation","keywords":"Biology; Transcription factor; Ex vivo; Kidney; Transplantation; Peroxisome proliferator-activated receptor; Cell biology; Receptor; In vivo; Medicine; Biochemistry; Internal medicine; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000439414,0.0002677479,0.0003960217,0.0003301354,0.0002346966,0.0003803188,0.0001621206,0.0002517058,0.0004992164],"category_scores_gemma":[0.0002904107,0.0001476617,0.0003527383,0.0003411387,0.0002565122,0.0002627063,0.0002499224,0.0003228511,0.0001585934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001540229,"about_ca_system_score_gemma":0.0002104349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003943962,"about_ca_topic_score_gemma":0.0007677477,"domain_scores_codex":[0.9997727,0.00002237322,0.00001769408,0.00008025816,0.00007286163,0.00003424724],"domain_scores_gemma":[0.9997982,0.00003259185,0.0000616369,0.00003134528,0.00005246534,0.00002377452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001834322,0.00001856124,0.001915297,0.00004895662,0.00002187591,0.00005351424,0.00002030416,0.00009632433,0.9962143,0.00001905477,0.00004102969,0.001367252],"study_design_scores_gemma":[0.00002622485,0.0009045762,0.215491,0.00002504933,0.0002236201,0.001181527,0.0001304905,0.003708529,0.7744284,0.0001918511,0.003652737,0.00003599644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868698,0.0007451297,0.01028777,0.00005190983,0.00002590836,0.0000488643,0.001510616,0.00007332239,0.0003867026],"genre_scores_gemma":[0.9747376,0.001390476,0.01583839,0.0002100131,0.00002769431,0.0002092394,0.006472762,0.00007722936,0.001036572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004992164,"threshold_uncertainty_score":0.002323925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032438060477818,"score_gpt":0.2502027120131859,"score_spread":0.2398783314084078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}