{"id":"W3165563222","doi":"10.1038/s41467-021-23402-7","title":"Ecology and molecular targets of hypermutation in the global microbiome","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of British Columbia; Agriculture and Agri-Food Canada","funders":"Lawrence Berkeley National Laboratory; California NanoSystems Institute; Biological and Environmental Research; Australian Research Council; Natural Sciences and Engineering Research Council of Canada; University of California, Santa Barbara; Office of Science; Beef Cattle Research Council; Genome British Columbia; National Energy Research Scientific Computing Center; Joint Genome Institute; Genome Canada; U.S. Department of Energy; Agriculture and Agri-Food Canada; National Science Foundation; Compute Canada; Alberta Beef Producers; Marine Biological Laboratory; Government of Canada","keywords":"Biology; Somatic hypermutation; Organism; Genome; Gene; Microbiome; Genetics; Evolutionary biology; Computational biology; Model organism; Molecular evolution","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007008042,0.00003710713,0.00005108547,0.000009725152,0.0000627648,0.00001054381,0.0002621261,0.00007355165,0.00008616118],"category_scores_gemma":[0.00003860934,0.00003110937,0.00002016492,0.0002273778,0.0001226113,0.00005552069,0.0002150775,0.0001957335,0.00001261919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004403379,"about_ca_system_score_gemma":0.000008850057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008952954,"about_ca_topic_score_gemma":0.003923532,"domain_scores_codex":[0.9996314,0.0001098314,0.00009311448,0.0000761167,0.00003007226,0.00005948623],"domain_scores_gemma":[0.9994841,0.00005894512,0.00003477452,0.0003986325,0.00001271727,0.00001079518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000002494219,0.0001855002,0.0218725,0.000002853425,0.000008776688,0.000004921254,0.0004186571,0.0000166023,0.970433,0.005020249,0.000890109,0.001144368],"study_design_scores_gemma":[0.0001388907,0.00001176565,0.939582,0.000005825434,0.00001374887,0.00009501163,0.0002512393,0.00004896855,0.006627657,0.0006997125,0.05246863,0.00005656289],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817798,0.001526195,0.00002908319,0.01016048,0.00005290503,0.0000880059,0.000030761,0.00000472204,0.006328051],"genre_scores_gemma":[0.9952581,0.0001637576,0.003521546,0.0009784596,0.000002095335,0.000006770742,0.00004633093,0.000001880362,0.00002104797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9638053,"threshold_uncertainty_score":0.2189423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006619967423708155,"score_gpt":0.2738956790234075,"score_spread":0.2672757115996994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}