{"id":"W3165563222","doi":"10.1038/s41467-021-23402-7","title":"Ecology and molecular targets of hypermutation in the global microbiome","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of British Columbia; Agriculture and Agri-Food Canada","funders":"Lawrence Berkeley National Laboratory; California NanoSystems Institute; Biological and Environmental Research; Australian Research Council; Natural Sciences and Engineering Research Council of Canada; University of California, Santa Barbara; Office of Science; Beef Cattle Research Council; Genome British Columbia; National Energy Research Scientific Computing Center; Joint Genome Institute; Genome Canada; U.S. Department of Energy; Agriculture and Agri-Food Canada; National Science Foundation; Compute Canada; Alberta Beef Producers; Marine Biological Laboratory; Government of Canada","keywords":"Biology; Somatic hypermutation; Organism; Genome; Gene; Microbiome; Genetics; Evolutionary biology; Computational biology; Model organism; Molecular evolution","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004040947,0.0002028231,0.0004267162,0.001110968,0.0003268082,0.0009794352,0.0001792746,0.0006358387,0.00152551],"category_scores_gemma":[0.0009938362,0.0001749602,0.0002870822,0.0009681631,0.0004795474,0.0006005857,0.0009261673,0.0004000035,0.0002807723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003016896,"about_ca_system_score_gemma":0.0002934705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192617,"about_ca_topic_score_gemma":0.001474118,"domain_scores_codex":[0.9994443,0.00007171016,0.00002799701,0.0002127068,0.00009196954,0.0001512392],"domain_scores_gemma":[0.9994019,0.0001133473,0.0002580574,0.0000443706,0.00007438065,0.0001079953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004582127,0.00009168364,0.4666529,0.0004429795,0.0003203441,0.0003000954,0.0006680439,0.001268105,0.4857334,0.001872346,0.0006276395,0.04156419],"study_design_scores_gemma":[0.000008434678,0.0001263084,0.9854527,0.00003540724,0.00005143711,0.0004411112,0.0006853524,0.001604656,0.00710256,0.001481796,0.002989116,0.00002104127],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956009,0.001624173,0.0007086748,0.0001278835,0.000009302255,0.000008710371,0.0006984916,0.00002751322,0.001194482],"genre_scores_gemma":[0.9974284,0.0006591299,0.0008311858,0.000103152,0.00001565836,0.00001394822,0.0006182049,0.00001579314,0.0003145128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00152551,"threshold_uncertainty_score":0.00510335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006619967423708155,"score_gpt":0.2738956790234075,"score_spread":0.2672757115996994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}