{"id":"W3165571064","doi":"10.1016/j.lungcan.2021.05.021","title":"A phase I study of binimetinib (MEK 162), a MEK inhibitor, plus carboplatin and pemetrexed chemotherapy in non-squamous non-small cell lung cancer","year":2021,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakeridge Health; Trillium Health Centre; University Health Network; University of Toronto; St Joseph's Health Centre; Princess Margaret Cancer Centre; Markham Stouffville Hospital; Queen's University","funders":"Novartis Pharmaceuticals Canada; Princess Margaret Cancer Foundation; Array BioPharma","keywords":"Medicine; Pemetrexed; Carboplatin; KRAS; Internal medicine; Oncology; MEK inhibitor; Lung cancer; Neuroblastoma RAS viral oncogene homolog; Adverse effect; Rash; Trametinib; Chemotherapy; Cancer; Colorectal cancer; MAPK/ERK pathway; Kinase; Cisplatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100475,0.00141722,0.002530461,0.0004890803,0.0004973431,0.001151375,0.001028513,0.001261,0.004501763],"category_scores_gemma":[0.0007098209,0.0007961186,0.00175273,0.0005000784,0.0008209825,0.0009447924,0.0003295844,0.004074497,0.001022225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001126853,"about_ca_system_score_gemma":0.001857376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002455697,"about_ca_topic_score_gemma":0.006506229,"domain_scores_codex":[0.9997104,0.0001001609,0.00001327475,0.00006435921,0.00002524435,0.00008662735],"domain_scores_gemma":[0.999487,0.00006710263,0.00005326927,0.0000369303,0.0000302846,0.000325398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7933124,0.09621749,0.002211025,0.001023646,0.001653565,0.0002221193,0.0002156401,0.002737478,0.03297499,0.0003268524,0.003748333,0.06535647],"study_design_scores_gemma":[0.5885312,0.3982514,0.005999054,0.00003539182,0.0006220279,0.0002146531,0.00007964671,0.001103662,0.002683476,0.0001904445,0.002253996,0.00003507921],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899703,0.002846461,0.0004473011,0.000538077,0.0003154152,0.002221236,0.001036393,0.0001040794,0.002520802],"genre_scores_gemma":[0.9840679,0.003796752,0.001723523,0.000933507,0.0002127758,0.002255595,0.002394194,0.00004343457,0.004572291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004501763,"threshold_uncertainty_score":0.01505989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210631720444915,"score_gpt":0.3448303173176637,"score_spread":0.3327240001132145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}