{"id":"W3165571064","doi":"10.1016/j.lungcan.2021.05.021","title":"A phase I study of binimetinib (MEK 162), a MEK inhibitor, plus carboplatin and pemetrexed chemotherapy in non-squamous non-small cell lung cancer","year":2021,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakeridge Health; Trillium Health Centre; University Health Network; University of Toronto; St Joseph's Health Centre; Princess Margaret Cancer Centre; Markham Stouffville Hospital; Queen's University","funders":"Novartis Pharmaceuticals Canada; Princess Margaret Cancer Foundation; Array BioPharma","keywords":"Medicine; Pemetrexed; Carboplatin; KRAS; Internal medicine; Oncology; MEK inhibitor; Lung cancer; Neuroblastoma RAS viral oncogene homolog; Adverse effect; Rash; Trametinib; Chemotherapy; Cancer; Colorectal cancer; MAPK/ERK pathway; Kinase; Cisplatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001323271,0.0003465338,0.0007739692,0.0002426314,0.00008311241,0.00003045233,0.00008771785,0.0001207645,0.0003779072],"category_scores_gemma":[0.00002469812,0.0003107306,0.0001045375,0.0008072027,0.00005429826,0.00008611718,0.0000571278,0.0002641953,0.000001201114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007308167,"about_ca_system_score_gemma":0.00117219,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01157487,"about_ca_topic_score_gemma":0.007619585,"domain_scores_codex":[0.9979615,0.00006378612,0.0005564519,0.0006429204,0.0003564654,0.0004188869],"domain_scores_gemma":[0.9988285,0.000110745,0.0002275813,0.0004053961,0.0002287868,0.0001990126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.003061293,0.01295423,0.7555379,0.003039379,0.002507605,0.0008997959,0.1016726,0.0009540032,0.07995285,0.000009284215,0.006820273,0.03259074],"study_design_scores_gemma":[0.3886925,0.006812934,0.3434603,0.003996994,0.009121327,0.0000636949,0.02741834,0.03712397,0.1776474,0.00002107738,0.003376788,0.002264626],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796979,0.01551757,0.00005120791,0.000507157,0.000443458,0.002098161,0.00011686,0.00003372936,0.001533902],"genre_scores_gemma":[0.9943527,0.001080875,0.0004021573,0.0004206453,0.0002387739,0.0009299295,0.00004307043,0.00007760711,0.002454265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4120776,"threshold_uncertainty_score":0.9999345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210631720444915,"score_gpt":0.3448303173176637,"score_spread":0.3327240001132145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}