{"id":"W3165577823","doi":"10.1136/annrheumdis-2021-eular.325","title":"AB0198 EFFICACY AND SAFETY AFTER TRANSITION FROM REFERENCE ADALIMUMAB TO CT-P17 (ADALIMUMAB BIOSIMILAR: 100 MG/ML) IN COMPARISON WITH THE MAINTAINED TREATMENT (CT-P17 OR REFERENCE ADALIMUMAB) IN PATIENTS WITH MODERATE-TO-SEVERE ACTIVE RHEUMATOID ARTHRITIS: 1-YEAR RESULT","year":2021,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Adalimumab; Medicine; Internal medicine; Rheumatoid arthritis; Randomization; Immunogenicity; Biosimilar; Gastroenterology; Nuclear medicine; Randomized controlled trial; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002498445,0.0004935954,0.001022335,0.0001335518,0.0002250995,0.00007053429,0.0003777566,0.0001233181,0.0003041239],"category_scores_gemma":[0.0002412492,0.0002590822,0.0001075705,0.0005615549,0.0003466747,0.0001658314,0.000163777,0.0003199077,0.00001616977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001052076,"about_ca_system_score_gemma":0.000273581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009633434,"about_ca_topic_score_gemma":0.003992661,"domain_scores_codex":[0.9966096,0.001054793,0.0007848821,0.0007392397,0.0002354866,0.0005760114],"domain_scores_gemma":[0.9977451,0.0007871611,0.0002682929,0.0008120431,0.0002440628,0.0001433375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5541578,0.02218132,0.08024316,0.0007436611,0.007484239,0.0003694874,0.02188603,0.004449953,0.001556421,0.001813392,0.006324447,0.2987901],"study_design_scores_gemma":[0.02834931,0.003950684,0.9372038,0.007641795,0.0003842502,0.00003049707,0.005649714,0.0001789693,0.01307257,0.0008010995,0.001562048,0.001175288],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889301,0.001822468,0.00007970357,0.005590029,0.00005633285,0.001214587,0.002173891,0.00002932321,0.0001035336],"genre_scores_gemma":[0.9966037,0.001324185,0.0004322469,0.001132379,0.000005201456,0.0001422549,0.0002273392,0.00003283451,0.0000998564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8569606,"threshold_uncertainty_score":0.9999861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03003932335974003,"score_gpt":0.2870993156697347,"score_spread":0.2570599923099947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}