{"id":"W3165664607","doi":"10.3389/fonc.2021.662392","title":"Assessment of the Clinical Trials Safety Profile of PD-1/PD-L1 Inhibitors Among Patients With Cancer: An Updated Systematic Review and Meta-Analysis","year":2021,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Shandong First Medical University; Natural Science Foundation of Shandong Province","keywords":"Medicine; Meta-analysis; Clinical trial; Cancer; Safety profile; Oncology; Systematic review; Internal medicine; MEDLINE; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02793948,0.001961822,0.01284367,0.006096764,0.0004218153,0.002960271,0.001672639,0.001783664,0.002689411],"category_scores_gemma":[0.05866981,0.001151982,0.03221411,0.006605683,0.0005539561,0.001667327,0.001212806,0.001500388,0.0002453775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002263093,"about_ca_system_score_gemma":0.00298997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004298398,"about_ca_topic_score_gemma":0.007999063,"domain_scores_codex":[0.9811943,0.009473358,0.005413318,0.001632257,0.001921271,0.0003654106],"domain_scores_gemma":[0.9513617,0.0356486,0.008021596,0.001685825,0.002956257,0.0003259904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001978239,0.00002218097,0.006507825,0.2379567,0.7308685,0.0001081285,0.00005796009,0.0007523199,0.0002712203,0.000176747,0.0009549991,0.02034528],"study_design_scores_gemma":[0.0005510332,0.0001731249,0.005686501,0.01699655,0.9737276,0.0001091113,0.00002207951,0.0002103255,0.0001292758,0.0002463851,0.002127862,0.00002009228],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004555392,0.9928131,0.0009244164,0.0003124753,0.0001658041,0.0001921909,0.0007209344,0.00002490879,0.0002908218],"genre_scores_gemma":[0.2615646,0.729288,0.003875369,0.001540213,0.0005203987,0.001205361,0.001602517,0.00005278962,0.0003507136],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02793948,"threshold_uncertainty_score":0.1477599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1175226406327143,"score_gpt":0.4744646237762179,"score_spread":0.3569419831435036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}