{"id":"W3165701213","doi":"10.1158/1078-0432.ccr-21-1625","title":"Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Abbotsford Veterinary Clinic; University of the Fraser Valley; Interior Health; BC Cancer Agency; Spinal Cord Injury BC; Island Health; University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canadian Cancer Society; Prostate Cancer Canada; Institute of Cancer Research; Jane ja Aatos Erkon Säätiö; Prostate Cancer Foundation; Government of Canada; Academy of Finland","keywords":"Enzalutamide; Prostate cancer; Androgen receptor; Somatic cell; Cancer research; Oncology; Biology; Genotype; Mutation; Internal medicine; Cancer; Abiraterone; Exome sequencing; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001742972,0.0001509062,0.0004614228,0.0002769626,0.0001494879,0.00003565354,0.00009141338,0.0002047751,0.001323135],"category_scores_gemma":[0.0004542836,0.0001299929,0.0001634165,0.001194547,0.0004662721,0.0001571454,0.0001451173,0.0009107289,0.00002621315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001492351,"about_ca_system_score_gemma":0.004780836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002044505,"about_ca_topic_score_gemma":0.003078786,"domain_scores_codex":[0.9962072,0.0006092866,0.0008398048,0.0006201373,0.00107176,0.0006518173],"domain_scores_gemma":[0.9977996,0.0002170855,0.0001132753,0.0003602912,0.001224658,0.0002850553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00775181,0.0008903385,0.2740348,0.000926775,0.0001591892,0.0006260123,0.0004586257,0.00006434966,0.703849,0.0001933268,0.0006934642,0.01035232],"study_design_scores_gemma":[0.01154012,0.0009289392,0.3139322,0.001969366,0.00004689491,0.00001556061,0.0009112298,0.0001308611,0.6673664,0.0004417386,0.002470612,0.0002461359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863022,0.00885129,0.0000023796,0.002781747,0.000269004,0.0009239693,0.0002902798,0.00002274827,0.0005563872],"genre_scores_gemma":[0.9878634,0.007684095,0.00006710328,0.00002159472,0.0004856263,0.0004543658,0.0001015187,0.0000312938,0.003290999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03989736,"threshold_uncertainty_score":0.9995898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1548736304656693,"score_gpt":0.4822969945088378,"score_spread":0.3274233640431685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}