{"id":"W3165701213","doi":"10.1158/1078-0432.ccr-21-1625","title":"Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Abbotsford Veterinary Clinic; University of the Fraser Valley; Interior Health; BC Cancer Agency; Spinal Cord Injury BC; Island Health; University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canadian Cancer Society; Prostate Cancer Canada; Institute of Cancer Research; Jane ja Aatos Erkon Säätiö; Prostate Cancer Foundation; Government of Canada; Academy of Finland","keywords":"Enzalutamide; Prostate cancer; Androgen receptor; Somatic cell; Cancer research; Oncology; Biology; Genotype; Mutation; Internal medicine; Cancer; Abiraterone; Exome sequencing; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000247339,0.0001711221,0.0002752083,0.0003463474,0.0001944242,0.000442713,0.000230329,0.0002332074,0.001646275],"category_scores_gemma":[0.0008550349,0.0001471395,0.0001411221,0.0004025974,0.0002172223,0.0002060337,0.0002740839,0.0004525796,0.0001891338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895201,"about_ca_system_score_gemma":0.0003188733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001487432,"about_ca_topic_score_gemma":0.001948281,"domain_scores_codex":[0.999741,0.0000408602,0.00001507573,0.00008732885,0.0000834267,0.00003234719],"domain_scores_gemma":[0.999554,0.00006098971,0.0002069295,0.00004113058,0.00005117212,0.0000857441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004932028,0.0004441256,0.5457566,0.0001540801,0.0002465413,0.0007694591,0.0003160267,0.002184291,0.3998494,0.0002938353,0.0004383032,0.04461532],"study_design_scores_gemma":[0.00007788378,0.002354121,0.9526801,0.00001423726,0.00007600541,0.002596469,0.0001201675,0.002065268,0.0386336,0.0001443235,0.001224774,0.00001324443],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998679,0.0003222314,0.0003305257,0.00002342789,0.000002376556,0.00001689395,0.0002763016,0.00001461366,0.0003345986],"genre_scores_gemma":[0.9991382,0.00005390485,0.0001932059,0.00003108654,0.000002343812,0.00001095986,0.0003615736,0.000004039572,0.0002045242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646275,"threshold_uncertainty_score":0.00550735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1548736304656693,"score_gpt":0.4822969945088378,"score_spread":0.3274233640431685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}