{"id":"W3165705643","doi":"10.1038/s41467-021-23125-9","title":"Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research Council; Strong; University of Melbourne; National Health and Medical Research Council; State Government of Victoria; Australian Government; Stem Cells Australia","keywords":"Suicide gene; Induced pluripotent stem cell; Transplantation; Neural stem cell; Ganciclovir; Biology; Neuroscience; Parkinsonism; Progenitor cell; Dopamine; Stem cell; Cancer research; Cell biology; Medicine; Gene; Genetic enhancement; Pathology; Disease; Internal medicine; Embryonic stem cell; Human cytomegalovirus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004082254,0.0002734707,0.0002506562,0.000276975,0.0001051473,0.0003516313,0.0002035061,0.0003362582,0.0008191659],"category_scores_gemma":[0.0002432969,0.0001225325,0.0002008275,0.0001210354,0.0002955172,0.0001753322,0.0001806126,0.0005179723,0.0001909426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747842,"about_ca_system_score_gemma":0.0002091324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004588403,"about_ca_topic_score_gemma":0.0005145248,"domain_scores_codex":[0.9997036,0.00004964111,0.00003950946,0.00005541216,0.0001206311,0.00003120066],"domain_scores_gemma":[0.9998054,0.00004145629,0.00006174418,0.00003988637,0.00002844546,0.00002300484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005606756,0.000021911,0.0002625513,0.00001495254,0.000005888566,0.00002485087,0.0000151144,0.0001281613,0.9969792,0.0001313515,0.00002035237,0.002339396],"study_design_scores_gemma":[0.000008076273,0.0003552583,0.0009727364,0.000003298779,0.00001298952,0.0001475094,0.00001209029,0.0007893763,0.9968329,0.00003604557,0.0008276479,0.000002129056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895331,0.0004303388,0.008856249,0.00006879849,0.00002080751,0.00005584195,0.0001494458,0.0001275689,0.000757883],"genre_scores_gemma":[0.991269,0.0003007259,0.006433286,0.00002300275,0.000005915866,0.00002705924,0.0002130004,0.00002851643,0.001699478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008191659,"threshold_uncertainty_score":0.002740443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995584798437925,"score_gpt":0.3039344283516253,"score_spread":0.283978580367246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}