{"id":"W3165705643","doi":"10.1038/s41467-021-23125-9","title":"Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research Council; Strong; University of Melbourne; National Health and Medical Research Council; State Government of Victoria; Australian Government; Stem Cells Australia","keywords":"Suicide gene; Induced pluripotent stem cell; Transplantation; Neural stem cell; Ganciclovir; Biology; Neuroscience; Parkinsonism; Progenitor cell; Dopamine; Stem cell; Cancer research; Cell biology; Medicine; Gene; Genetic enhancement; Pathology; Disease; Internal medicine; Embryonic stem cell; Human cytomegalovirus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075688,0.00007757708,0.0001055038,0.00003076546,0.0001576148,0.00001916778,0.0004025154,0.0001503102,0.000002193316],"category_scores_gemma":[0.00002258554,0.00006606896,0.00003974052,0.0001281915,0.0001052038,0.000004943469,0.0002294539,0.0003792425,3.112729e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002027665,"about_ca_system_score_gemma":0.00007136894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002774065,"about_ca_topic_score_gemma":0.001342753,"domain_scores_codex":[0.9991274,0.0002427796,0.0001983631,0.0001689354,0.0001286286,0.000133926],"domain_scores_gemma":[0.9988201,0.00005643148,0.00005925619,0.0009187203,0.0001121027,0.00003339595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002752248,0.00003673226,0.004201691,0.0000165557,0.00002151714,0.000001729044,0.000123503,0.00004904993,0.993495,0.0001402797,0.00003110044,0.001855308],"study_design_scores_gemma":[0.0004558676,0.00003647701,0.03575969,0.00002780887,0.00001476539,0.000006459144,0.0001466227,0.0004135663,0.9540021,0.00001356715,0.009031474,0.00009160949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826247,0.01487524,0.00007646338,0.001508551,0.00004697284,0.0002413082,0.0001650856,0.000004734681,0.0004569126],"genre_scores_gemma":[0.9956093,0.00374493,0.0002934877,0.00007816249,0.00001829754,0.00001333039,0.0001178461,0.000009790337,0.000114897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03949292,"threshold_uncertainty_score":0.2694214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995584798437925,"score_gpt":0.3039344283516253,"score_spread":0.283978580367246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}