{"id":"W3165707191","doi":"10.1038/s41598-021-91165-8","title":"In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Tobacco Research Unit; Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Von Willebrand factor; Platelet; Medicine; Pharmacology; Hemostasis; Platelet activation; Ristocetin; Thrombin; Venom; In vivo; Immunology; Chemistry; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001095809,0.001241059,0.001884794,0.0002469667,0.000377798,0.001046148,0.0006417478,0.00159888,0.002946256],"category_scores_gemma":[0.001024427,0.0005408868,0.0008246888,0.0002382755,0.0008522121,0.0007960799,0.0002285989,0.002178639,0.0005427848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005621245,"about_ca_system_score_gemma":0.000870827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003485036,"about_ca_topic_score_gemma":0.0006616817,"domain_scores_codex":[0.9995764,0.0001744028,0.00003076221,0.00009853356,0.00004408598,0.00007585],"domain_scores_gemma":[0.9995235,0.00009636048,0.0001165645,0.00005856175,0.00004062884,0.0001643611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8601704,0.03570967,0.001313848,0.0006729457,0.0008705442,0.0001559081,0.0001218296,0.001303273,0.06244871,0.0003183974,0.001489169,0.03542529],"study_design_scores_gemma":[0.5282717,0.4565704,0.003118987,0.00003125324,0.0005346208,0.00016791,0.00004255973,0.001489899,0.007289256,0.0002920498,0.002156385,0.00003488876],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894922,0.00303878,0.001643051,0.0003311964,0.0003034156,0.003209102,0.0006908318,0.0001146368,0.001176817],"genre_scores_gemma":[0.9871615,0.002355101,0.002341129,0.0007154097,0.0003027543,0.003890932,0.001258237,0.00002521551,0.001949747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002946256,"threshold_uncertainty_score":0.009856224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04540589608629048,"score_gpt":0.3955071513593475,"score_spread":0.350101255273057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}