{"id":"W3165707212","doi":"10.21203/rs.3.rs-532921/v1","title":"Genome-Wide Interaction Analysis of Menopausal Hormone Therapy Use and Breast Cancer Risk Among 62,370 Women","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Toronto; BC Cancer Agency; University of British Columbia; Queen's University","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; Medical Research Council; Institut National Du Cancer; Centers for Disease Control and Prevention; Deutsche Gesetzliche Unfallversicherung; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung, Wissenschaft und Forschung; Institut Gustave-Roussy; National Health and Medical Research Council; Cancer Council Victoria; Deutsche Krebshilfe; Deutschen Konsortium für Translationale Krebsforschung; Fondation de France; Swedish Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; U.S. Department of Defense; Cancer Research UK; Programme Grants for Applied Research; Breast Cancer Research Foundation; McGill University; Robert Bosch Stiftung; Government of Canada; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Lon V. Smith Foundation; Eberhard Karls Universität Tübingen; Fondation du cancer du sein du Québec; Génome Québec; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; U.S. Department of Health and Human Services; European Commission; World Cancer Research Fund; Susan G. Komen for the Cure; Agency for Science, Technology and Research","keywords":"Breast cancer; Hormone therapy; Oncology; Medicine; Internal medicine; Gynecology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001462593,0.0003692016,0.0006987706,0.0009464009,0.0005651502,0.0006821365,0.0004846421,0.000513275,0.002474482],"category_scores_gemma":[0.003447998,0.0003425513,0.00178409,0.001914689,0.0003275987,0.0002396791,0.0004831124,0.0005131329,0.0001582482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164119,"about_ca_system_score_gemma":0.0004232789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01146696,"about_ca_topic_score_gemma":0.01263258,"domain_scores_codex":[0.9985348,0.0004944187,0.0001270297,0.0005343198,0.0001564639,0.0001530623],"domain_scores_gemma":[0.9979875,0.00101582,0.0004469066,0.0002547555,0.0001187274,0.0001763136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000923336,0.00002044162,0.9934394,0.00004099094,0.002422268,0.0001323072,0.00006836741,0.0001160157,0.001288499,0.00004121248,0.0001283278,0.001378891],"study_design_scores_gemma":[0.00004522529,0.0001529059,0.9971048,0.000009460724,0.00135417,0.0001774819,0.00008360985,0.0004813563,0.000185994,0.00007439726,0.0003243616,0.000006188456],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963489,0.001349828,0.0005406226,0.00008761072,0.00001780905,0.00001008929,0.001365392,0.00001795823,0.0002619073],"genre_scores_gemma":[0.9989254,0.000127242,0.0002193152,0.00002192737,0.00001014104,0.00001303588,0.0005248737,0.000004795664,0.0001533531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01146696,"threshold_uncertainty_score":0.02280039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128087008595821,"score_gpt":0.3366379994061838,"score_spread":0.3153571293202256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}