{"id":"W3165748221","doi":"10.1080/21691401.2021.1918134","title":"A polymer–lipid membrane artificial cell nanocarrier containing enzyme–oxygen biotherapeutic inhibits the growth of B16F10 melanoma in 3D culture and in a mouse model","year":2021,"lang":"en","type":"article","venue":"Artificial Cells Nanomedicine and Biotechnology","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nanocarriers; Cell growth; Enzyme; Artificial cell; Melanoma; Cell culture; Membrane; Chemistry; Cell; Cell biology; Biophysics; Nanotechnology; Materials science; Biochemistry; Biology; Cancer research; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002457929,0.0002942547,0.0005489336,0.0003689375,0.00006563777,0.0000204908,0.0001700928,0.0005254641,0.00001471951],"category_scores_gemma":[0.0000298212,0.0002298716,0.0000452801,0.0007730423,0.0003721981,0.00008985578,0.00008750657,0.0005062573,0.000002553437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005740889,"about_ca_system_score_gemma":0.00008390874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001221788,"about_ca_topic_score_gemma":0.001012392,"domain_scores_codex":[0.9983174,0.0000357707,0.0006425412,0.0003687867,0.0001661494,0.0004693035],"domain_scores_gemma":[0.9994241,0.00008614764,0.00009235494,0.0002824731,0.0000457616,0.00006915293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001275391,0.00006137398,0.000198904,0.0001281583,0.00003155884,0.00003026114,0.001617041,0.0003018585,0.9922582,0.000853556,0.00001192611,0.004379642],"study_design_scores_gemma":[0.0008427458,0.0002100177,0.00001883642,0.00007043363,0.0000347767,0.00001918827,0.001255282,0.01576452,0.9804679,0.0007761669,0.0002981044,0.000242014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910002,0.006746724,0.0005772753,0.0009091255,0.0001948996,0.0003048817,0.00004227343,0.00008932682,0.0001352676],"genre_scores_gemma":[0.9969933,0.002199874,0.0002890045,0.0002721746,0.00007773094,0.00001788447,0.00001117774,0.00004374197,0.00009508296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01546266,"threshold_uncertainty_score":0.937389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00946394395365671,"score_gpt":0.2019340409633462,"score_spread":0.1924700970096895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}