{"id":"W3165748221","doi":"10.1080/21691401.2021.1918134","title":"A polymer–lipid membrane artificial cell nanocarrier containing enzyme–oxygen biotherapeutic inhibits the growth of B16F10 melanoma in 3D culture and in a mouse model","year":2021,"lang":"en","type":"article","venue":"Artificial Cells Nanomedicine and Biotechnology","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nanocarriers; Cell growth; Enzyme; Artificial cell; Melanoma; Cell culture; Membrane; Chemistry; Cell; Cell biology; Biophysics; Nanotechnology; Materials science; Biochemistry; Biology; Cancer research; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001957335,0.0002918958,0.0002107574,0.000223705,0.000110606,0.0001737851,0.0001619734,0.0003277889,0.0005739177],"category_scores_gemma":[0.0000871924,0.0001054929,0.0002412638,0.00009773982,0.0002155783,0.0001954824,0.0001279037,0.0004389581,0.0002024904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387968,"about_ca_system_score_gemma":0.0002297694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009002099,"about_ca_topic_score_gemma":0.001467894,"domain_scores_codex":[0.999891,0.000016101,0.000008712511,0.00003049544,0.00003667352,0.00001697176],"domain_scores_gemma":[0.9999298,0.0000209795,0.00001887517,0.000007757701,0.000007485352,0.00001512337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000320782,0.00002509272,0.0000309356,0.0000236155,0.00000261851,0.0000166949,0.000007811798,0.00007340036,0.9988973,0.00005663864,0.00001861313,0.0008152042],"study_design_scores_gemma":[0.00000982795,0.0002996713,0.0003007956,0.000002382443,0.000009058846,0.00005094272,0.000003593998,0.0007205092,0.9973694,0.00001121721,0.001220135,0.000002423229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796109,0.002644282,0.01538815,0.0002390944,0.00009032139,0.00007812119,0.0001607318,0.000132707,0.001655816],"genre_scores_gemma":[0.9790744,0.001358286,0.01556535,0.0000674217,0.00001663862,0.00007250358,0.0001878554,0.00002372322,0.003633725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009002099,"threshold_uncertainty_score":0.001919925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00946394395365671,"score_gpt":0.2019340409633462,"score_spread":0.1924700970096895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}