{"id":"W3165780789","doi":"10.1371/journal.pbio.3001233","title":"Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology","year":2021,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institutes of Health; Servier; Eisai; National Institute of Neurological Disorders and Stroke; Northern California Institute for Research and Education; Pennsylvania State University; York University; Biogen; BioClinica; F. Hoffmann-La Roche; University of Pennsylvania; University of Southern California; Foundation for the National Institutes of Health; Boston College; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; National Institute on Aging; Alzheimer's Association; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Science Foundation","keywords":"Glymphatic system; Cerebrospinal fluid; Neuroimaging; Neuroscience; Disease; Alzheimer's disease; Pathology; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002665399,0.0003744247,0.0004021176,0.0008211182,0.0001615021,0.0004461052,0.0001630077,0.0002231103,0.0009191876],"category_scores_gemma":[0.0009885771,0.0001246109,0.0001755091,0.0004627194,0.0004341839,0.0002880094,0.0004271714,0.0003141302,0.00009035601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391467,"about_ca_system_score_gemma":0.0001201342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115074,"about_ca_topic_score_gemma":0.001256987,"domain_scores_codex":[0.9998844,0.00002136833,0.00001377351,0.00004613751,0.00001616299,0.00001807557],"domain_scores_gemma":[0.9995004,0.00009613511,0.0002578579,0.00004782099,0.00003668003,0.00006110165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003350237,0.0004579107,0.5902182,0.000370946,0.001251856,0.001956255,0.001282555,0.001093758,0.345489,0.0005942776,0.0008289691,0.05310605],"study_design_scores_gemma":[0.000005756967,0.0001135194,0.9952042,0.00000749428,0.00005188362,0.0004339868,0.00008170523,0.0005134383,0.00296405,0.0004385026,0.000176401,0.00000902724],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972342,0.000542608,0.001532647,0.00003322828,0.000008495118,0.000008808674,0.0002558078,0.00002672245,0.0003576099],"genre_scores_gemma":[0.9988059,0.0001973754,0.0005605927,0.00001935848,0.00001384716,0.00000973053,0.0002217123,0.000008872397,0.0001626813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115074,"threshold_uncertainty_score":0.003075004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04786971550240414,"score_gpt":0.3081959646579042,"score_spread":0.2603262491555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}