{"id":"W3165786465","doi":"10.1016/j.jcf.2021.05.004","title":"Effect of lumacaftor-ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis: Results from the PROSPECT MCC sub-study","year":2021,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Vertex Pharmaceuticals; Cystic Fibrosis Foundation","keywords":"Ivacaftor; Cystic fibrosis; Medicine; Mucociliary clearance; Lung function; Internal medicine; Cystic fibrosis transmembrane conductance regulator; Lung; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001758759,0.0007834887,0.001855587,0.0004051788,0.0003544203,0.0008027492,0.0005425998,0.0008274016,0.001376234],"category_scores_gemma":[0.002157694,0.0002352076,0.002318672,0.0005103656,0.0005622574,0.0009091712,0.000662622,0.001021445,0.000298684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007154649,"about_ca_system_score_gemma":0.0008821733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002838182,"about_ca_topic_score_gemma":0.004556481,"domain_scores_codex":[0.9990681,0.0003757911,0.00008480241,0.0001648863,0.0001453217,0.0001611652],"domain_scores_gemma":[0.9978842,0.0005707957,0.0006859844,0.0001658712,0.0001654951,0.000527561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6750878,0.009479846,0.2338477,0.0007363065,0.009714284,0.0002391598,0.0001728355,0.0004715915,0.004831753,0.0001074727,0.001242256,0.06406908],"study_design_scores_gemma":[0.05279477,0.126571,0.808758,0.0001659938,0.008275955,0.0002727519,0.0002429074,0.0005361121,0.001105587,0.00009788349,0.001114649,0.00006459796],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959648,0.002945655,0.00004430876,0.00008208425,0.00002015256,0.000064368,0.0004692765,0.000006900368,0.0004023735],"genre_scores_gemma":[0.9970758,0.00112367,0.0001567026,0.0001363439,0.0001061625,0.00008069883,0.0009730936,0.000004730908,0.0003428325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002838182,"threshold_uncertainty_score":0.009301305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612784240648195,"score_gpt":0.3453946709160198,"score_spread":0.3292668285095379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}