{"id":"W3165802374","doi":"10.1172/jci.insight.144920","title":"mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; National Institutes of Health; Emerson Collective; National Institute of General Medical Sciences; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; Fred Hutchinson Cancer Research Center; eFFECTOR Therapeutics; Burroughs Wellcome Fund; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; U.S. Department of Defense","keywords":"EIF4E; Bladder cancer; Cancer research; Phosphorylation; Eukaryotic translation; Serine; Translation (biology); Kinase; Cancer; Biology; Cell biology; Messenger RNA; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241429,0.0003825952,0.0004057828,0.0003638252,0.0002184267,0.000432348,0.0001590906,0.0004415938,0.002210652],"category_scores_gemma":[0.0002242078,0.0002237971,0.000415809,0.0001440074,0.0004266125,0.0002889412,0.0002865193,0.0007637434,0.0002849322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892207,"about_ca_system_score_gemma":0.0002962414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002302166,"about_ca_topic_score_gemma":0.0002904193,"domain_scores_codex":[0.9996902,0.00004869466,0.00002872684,0.00006880302,0.00009057322,0.00007309182],"domain_scores_gemma":[0.9997532,0.0000504557,0.0001021917,0.00003396166,0.00001765088,0.00004268758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007733393,0.00001449315,0.0001287187,0.00002183212,0.000003825189,0.00006570198,0.000005357396,0.00005284516,0.9984801,0.0001735268,0.00002226113,0.0009539759],"study_design_scores_gemma":[0.00001678708,0.0005610149,0.0028859,0.00001093098,0.00002615703,0.0008697373,0.00002307588,0.0005351086,0.9915001,0.0001537294,0.003410944,0.000006634329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980331,0.002382789,0.01194086,0.000526308,0.0001144473,0.00008759071,0.0004939434,0.0004087342,0.003714315],"genre_scores_gemma":[0.9948144,0.0009120618,0.002221949,0.00005160314,0.00001360037,0.00003958562,0.000239931,0.00003583712,0.001671059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210652,"threshold_uncertainty_score":0.007395327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05287860087478526,"score_gpt":0.3237166415879693,"score_spread":0.2708380407131841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}