{"id":"W3165802374","doi":"10.1172/jci.insight.144920","title":"mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; National Institutes of Health; Emerson Collective; National Institute of General Medical Sciences; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; Fred Hutchinson Cancer Research Center; eFFECTOR Therapeutics; Burroughs Wellcome Fund; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; U.S. Department of Defense","keywords":"EIF4E; Bladder cancer; Cancer research; Phosphorylation; Eukaryotic translation; Serine; Translation (biology); Kinase; Cancer; Biology; Cell biology; Messenger RNA; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009358591,0.0001527968,0.0002490116,0.00003832167,0.0001357322,0.00002687187,0.00004137284,0.0001234808,0.001232945],"category_scores_gemma":[0.000009538626,0.0001283024,0.0002002467,0.0001443504,0.00003547091,0.0001883717,0.000003635227,0.0001197524,0.00004671801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005688694,"about_ca_system_score_gemma":0.0002166021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004105085,"about_ca_topic_score_gemma":0.00005473051,"domain_scores_codex":[0.999016,0.00004444797,0.0002502986,0.0002705912,0.0002216457,0.0001970016],"domain_scores_gemma":[0.9994184,0.00005767779,0.00003956126,0.0002450996,0.0001530596,0.00008624609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002491093,0.001902866,0.002753456,0.0007334515,0.001142611,0.00003846942,0.04190933,0.00002119977,0.09516525,0.0007293719,0.00308417,0.8500288],"study_design_scores_gemma":[0.02045349,0.001402837,0.02996864,0.0001508492,0.001540891,0.0001106482,0.0008257534,0.003718556,0.4705585,0.01195269,0.4586951,0.0006220775],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6582896,0.01872632,0.1367316,0.06914084,0.002338905,0.006874221,0.0008883186,0.000594074,0.1064161],"genre_scores_gemma":[0.9939273,0.0002237868,0.001155619,0.003397282,0.0002761137,0.0001016037,0.0002121265,0.0000277961,0.0006783763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8494067,"threshold_uncertainty_score":0.99968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05287860087478526,"score_gpt":0.3237166415879693,"score_spread":0.2708380407131841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}