{"id":"W3165813555","doi":"10.1093/ecco-jcc/jjab089","title":"Ustekinumab in Paediatric Patients with Moderately to Severely Active Crohn’s Disease: Pharmacokinetics, Safety, and Efficacy Results from UniStar, a Phase 1 Study","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Janssen Pharmaceuticals","keywords":"Medicine; Adverse effect; Ustekinumab; Pharmacokinetics; Interquartile range; Tolerability; Crohn's disease; Internal medicine; Dosing; Gastroenterology; Discontinuation; Exacerbation; Population; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002516894,0.0005655804,0.001447844,0.000184591,0.0002295721,0.0004899157,0.0004239605,0.000539238,0.001623843],"category_scores_gemma":[0.001567774,0.0003549592,0.0008059811,0.0003503753,0.0006776187,0.00054427,0.0003228413,0.001786729,0.0003847853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005582732,"about_ca_system_score_gemma":0.001014227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005129417,"about_ca_topic_score_gemma":0.001733498,"domain_scores_codex":[0.9991245,0.0005362996,0.00006941566,0.00008129239,0.0001247602,0.00006379855],"domain_scores_gemma":[0.9985427,0.0003392114,0.0005624872,0.0001171937,0.0001196292,0.0003188152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5036559,0.03535432,0.08793533,0.004220228,0.002474155,0.001086626,0.001902219,0.002429686,0.09772015,0.0003416426,0.00630698,0.2565729],"study_design_scores_gemma":[0.2427407,0.5317858,0.2010719,0.0002382943,0.00140269,0.002912569,0.0002870639,0.001159467,0.01006627,0.0001312491,0.008143614,0.00006040138],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920114,0.005722464,0.0003166686,0.0002018194,0.00002290151,0.0004420177,0.0004226923,0.00004007132,0.0008200179],"genre_scores_gemma":[0.9924535,0.00375586,0.001387468,0.0004172169,0.00006633003,0.0003276156,0.001134596,0.00001881851,0.0004386173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002516894,"threshold_uncertainty_score":0.01331079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007564979470243492,"score_gpt":0.2569612732227829,"score_spread":0.2493962937525395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}