{"id":"W3165814839","doi":"10.1085/jgp.202012855","title":"Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1","year":2021,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs; National Institute of Neurological Disorders and Stroke; National Alliance for Research on Schizophrenia and Depression","keywords":"Desensitization (medicine); Ion channel; Biophysics; Chemistry; Glutamine; Ligand-gated ion channel; Homologous desensitization; Biochemistry; Amino acid; Biology; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002109036,0.0003771132,0.0003482765,0.0001368317,0.0001694007,0.0002186234,0.0004935631,0.0004657693,0.002900699],"category_scores_gemma":[0.0002798295,0.000168563,0.0003870697,0.000177094,0.0004189716,0.0001812528,0.0002722607,0.0006617161,0.0007771209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003023034,"about_ca_system_score_gemma":0.0002976288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222762,"about_ca_topic_score_gemma":0.001063048,"domain_scores_codex":[0.9997417,0.00004608819,0.00004255572,0.00005316975,0.00007482649,0.00004164722],"domain_scores_gemma":[0.9997622,0.00006286446,0.00005773952,0.0000445401,0.00002309956,0.00004956739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384154,0.00005627599,0.0001290894,0.00003343945,0.00001454332,0.0001179706,0.00001563209,0.0001271491,0.9984054,0.0001354591,0.00007551949,0.0007512011],"study_design_scores_gemma":[0.00008337794,0.0006306936,0.003499341,0.00001301566,0.00003216892,0.0008947148,0.00003112714,0.002326052,0.9868807,0.00008920902,0.005505283,0.00001440458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950373,0.0005357152,0.002277639,0.0001052608,0.00006735776,0.00004234771,0.0004858763,0.00009268364,0.00135578],"genre_scores_gemma":[0.9943365,0.0003563967,0.001909382,0.0001033003,0.00001084526,0.00003284375,0.0008543913,0.0000852928,0.002311055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002900699,"threshold_uncertainty_score":0.009703755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283408286884631,"score_gpt":0.241213159667225,"score_spread":0.2283790767983787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}