{"id":"W3165814839","doi":"10.1085/jgp.202012855","title":"Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1","year":2021,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs; National Institute of Neurological Disorders and Stroke; National Alliance for Research on Schizophrenia and Depression","keywords":"Desensitization (medicine); Ion channel; Biophysics; Chemistry; Glutamine; Ligand-gated ion channel; Homologous desensitization; Biochemistry; Amino acid; Biology; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002701113,0.0000795409,0.0001984593,0.00005146038,0.00004428987,0.000003297899,0.00006270302,0.00009922154,0.0000102347],"category_scores_gemma":[0.000171912,0.00005250093,0.00009130359,0.0001036174,0.00009724239,0.000007228739,0.00003482157,0.00006564098,4.066539e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008301856,"about_ca_system_score_gemma":0.00008500332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002036981,"about_ca_topic_score_gemma":0.00002338447,"domain_scores_codex":[0.9990487,0.0002842113,0.0003772742,0.00008728205,0.0001114058,0.00009111029],"domain_scores_gemma":[0.998516,0.0000243564,0.0004986359,0.0001371602,0.0007981109,0.00002577965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006047455,0.00002954291,0.00001444087,0.00001936514,0.00005535513,0.000001861919,0.0001357253,0.009908492,0.9884372,0.00004965631,0.000255737,0.0004879099],"study_design_scores_gemma":[0.0005769132,0.0002406736,0.008296997,0.00002025988,0.00003781045,0.0001161617,0.0002299036,0.002183306,0.9875972,0.0005427306,0.000102995,0.00005509189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928163,0.0002230674,0.005851347,0.0004355831,0.0005862166,0.00004726928,0.000008435682,0.000001782615,0.00003003158],"genre_scores_gemma":[0.9981105,0.0002283468,0.0004439357,0.0002160213,0.0007419357,2.306825e-7,0.00006987342,0.000008963223,0.000180193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008282556,"threshold_uncertainty_score":0.2140926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283408286884631,"score_gpt":0.241213159667225,"score_spread":0.2283790767983787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}