{"id":"W3165821120","doi":"10.1248/bpb.b21-00076","title":"Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes","year":2021,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Alberta","keywords":"Bicarbonate; Antibody; Extracellular; Urinary system; Chemistry; Extracellular fluid; Medicine; Pharmacology; Internal medicine; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233839,0.0001955137,0.0004416413,0.0001596083,0.00007254099,0.0001916099,0.0001130394,0.0001814799,0.0007301742],"category_scores_gemma":[0.0001264196,0.00007583494,0.0001601381,0.0001127385,0.0001421437,0.0002047631,0.000127626,0.0005631617,0.00007260119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001414223,"about_ca_system_score_gemma":0.0002252458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003724035,"about_ca_topic_score_gemma":0.0008927109,"domain_scores_codex":[0.9999316,0.00001097341,0.000006395311,0.00001265249,0.00002076053,0.000017666],"domain_scores_gemma":[0.999928,0.000009520903,0.00002297203,0.000005728622,0.000007767667,0.00002595678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002947058,0.0005112477,0.001217212,0.0001236023,0.0000249572,0.00002989072,0.00001939237,0.0001574296,0.9802064,0.00002636205,0.00009487066,0.01464151],"study_design_scores_gemma":[0.0005071897,0.02275357,0.03002391,0.00001899323,0.0001563106,0.0002860295,0.00007077971,0.002132149,0.9403369,0.00008686763,0.003608977,0.00001833789],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963802,0.002656433,0.0004222003,0.00006913362,0.00003198891,0.00002323406,0.00006273216,0.00002464483,0.0003294619],"genre_scores_gemma":[0.9974999,0.001009178,0.0006029782,0.00005645771,0.00001770815,0.00002211525,0.0001024032,0.000005277155,0.0006840175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007301742,"threshold_uncertainty_score":0.002442718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06546135940176276,"score_gpt":0.3435688910026518,"score_spread":0.278107531600889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}