{"id":"W3165821120","doi":"10.1248/bpb.b21-00076","title":"Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes","year":2021,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Alberta","keywords":"Bicarbonate; Antibody; Extracellular; Urinary system; Chemistry; Extracellular fluid; Medicine; Pharmacology; Internal medicine; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006462971,0.0001950733,0.0003828268,0.00003090853,0.0001327766,0.00002371374,0.0001024442,0.0001690929,0.00004951265],"category_scores_gemma":[0.0002773551,0.0001555208,0.00008356433,0.00009093311,0.0003783491,0.000006809036,0.0001206016,0.0001798527,0.000001007127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005262802,"about_ca_system_score_gemma":0.00005400232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001635141,"about_ca_topic_score_gemma":5.744333e-7,"domain_scores_codex":[0.9980937,0.0006599724,0.0004417007,0.0004446519,0.0001118423,0.0002480793],"domain_scores_gemma":[0.9991572,0.0002093734,0.0001613238,0.0001931373,0.0001016919,0.0001772419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002378771,0.0001688811,0.168622,0.00003625167,0.00006409427,0.00000252804,0.00002125683,5.483299e-7,0.8273438,0.0002490097,0.00002721389,0.003226562],"study_design_scores_gemma":[0.001013295,0.0003546454,0.4575519,0.00002337134,0.0001248792,0.00005527907,0.0001243506,0.00005389189,0.4736376,0.0001667589,0.06664895,0.0002451224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701796,0.0281175,0.0002180765,0.0009384301,0.00009030759,0.0002155841,0.0002016152,0.00001211642,0.00002676678],"genre_scores_gemma":[0.9923259,0.006248194,0.0007324666,0.0002150629,0.0001449416,0.000008864065,0.0002677602,0.00001242635,0.00004437651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3537062,"threshold_uncertainty_score":0.6341955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06546135940176276,"score_gpt":0.3435688910026518,"score_spread":0.278107531600889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}