{"id":"W3165824615","doi":"10.1093/jpp/rgab053","title":"<i>Dioscorea zingiberensis</i> ameliorates diabetic nephropathy by inhibiting NLRP3 inflammasome and curbing the expression of p66Shc in high-fat diet/streptozotocin-induced diabetic mice","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Jiangsu National Synergistic Innovation Center for Advanced Materials; National Natural Science Foundation of China","keywords":"Diabetic nephropathy; Streptozotocin; Oxidative stress; Inflammasome; Kidney; Blood urea nitrogen; Medicine; Diabetes mellitus; Endocrinology; Internal medicine; Renal function; Renal Hypertrophy; Creatinine; Pharmacology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006203269,0.0004870605,0.0003305363,0.0003652693,0.0001869085,0.0001694891,0.0001636539,0.0001812785,0.001259217],"category_scores_gemma":[0.00003830385,0.00008482398,0.0002659507,0.0002073447,0.0001444157,0.0002503753,0.0001384167,0.0005487964,0.0001870745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743782,"about_ca_system_score_gemma":0.0001526794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000977106,"about_ca_topic_score_gemma":0.001198485,"domain_scores_codex":[0.9999644,0.000003472131,0.000004203723,0.000007734824,0.00001004954,0.00001029587],"domain_scores_gemma":[0.9999775,0.000001223744,0.000008811477,0.000001717402,0.000003756664,0.000006947873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006050622,0.0001779651,0.000436322,0.0003704911,0.00003094823,0.00007537944,0.00001417621,0.00007320882,0.9906364,0.0001408279,0.0002417204,0.007197381],"study_design_scores_gemma":[0.0004276088,0.003296169,0.0454226,0.00006517766,0.0002461969,0.0008704954,0.00007418507,0.001430593,0.9268494,0.0003073874,0.02098426,0.00002601922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842961,0.007391808,0.002754881,0.0003842135,0.0001144996,0.00008779333,0.0008280564,0.0002506684,0.003892004],"genre_scores_gemma":[0.989773,0.004130647,0.00202342,0.0002593122,0.00003656928,0.00004750327,0.0009580553,0.00001872311,0.002752873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259217,"threshold_uncertainty_score":0.004212499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008164171739650951,"score_gpt":0.257960147208392,"score_spread":0.249795975468741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}