{"id":"W3165824615","doi":"10.1093/jpp/rgab053","title":"<i>Dioscorea zingiberensis</i> ameliorates diabetic nephropathy by inhibiting NLRP3 inflammasome and curbing the expression of p66Shc in high-fat diet/streptozotocin-induced diabetic mice","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Jiangsu National Synergistic Innovation Center for Advanced Materials; National Natural Science Foundation of China","keywords":"Diabetic nephropathy; Streptozotocin; Oxidative stress; Inflammasome; Kidney; Blood urea nitrogen; Medicine; Diabetes mellitus; Endocrinology; Internal medicine; Renal function; Renal Hypertrophy; Creatinine; Pharmacology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004740116,0.0002366047,0.0004149515,0.0000969777,0.0001396613,0.00003099255,0.0001750847,0.000106197,0.00005515262],"category_scores_gemma":[0.00009798703,0.0001896949,0.0001034024,0.0001924572,0.0001786021,0.00003880433,0.0002175054,0.0004353028,8.590936e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001460087,"about_ca_system_score_gemma":0.00009434816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000219627,"about_ca_topic_score_gemma":0.00000676704,"domain_scores_codex":[0.9981359,0.0004034076,0.0006984245,0.0002659907,0.0001491348,0.0003471705],"domain_scores_gemma":[0.9988934,0.0001482952,0.0005304531,0.0001072279,0.0002175632,0.0001030994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004574283,0.000111729,0.01204733,0.0001044043,0.00008776256,0.00004478216,0.0004620798,0.00004222436,0.9829592,0.000003955966,0.0012082,0.002470881],"study_design_scores_gemma":[0.004052948,0.0003303123,0.0009766757,0.00009937397,0.0001428136,0.00006747983,0.0004832773,0.00006834642,0.9905415,0.00006268392,0.00297494,0.0001996686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985443,0.01321851,0.00001490097,0.0006882373,0.0003819136,0.0001811989,0.00001143625,0.000003368465,0.00005744525],"genre_scores_gemma":[0.9947728,0.004038282,0.0000818373,0.0007357245,0.0002875769,0.00001332044,0.00001929578,0.00002448085,0.00002667575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01107065,"threshold_uncertainty_score":0.7735533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008164171739650951,"score_gpt":0.257960147208392,"score_spread":0.249795975468741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}