{"id":"W3165836291","doi":"10.1111/bph.15573","title":"The anomalous pharmacology of fentanyl","year":2021,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Medical Research Council Canada","keywords":"Fentanyl; Opioid; Morphine; (+)-Naloxone; Pharmacology; Medicine; Opioid overdose; Anesthesia; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000941994,0.0002847985,0.001418217,0.00008467176,0.0001605562,0.0000424797,0.0007630697,0.0004233199,0.0008038252],"category_scores_gemma":[0.00007612077,0.0002471581,0.001020126,0.0001613524,0.0001924552,0.000004976714,0.0002217673,0.0006523148,0.000003864067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000432533,"about_ca_system_score_gemma":0.0008301312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006081518,"about_ca_topic_score_gemma":0.000004168015,"domain_scores_codex":[0.9969553,0.0008719594,0.00128733,0.0002873665,0.0002102175,0.0003878377],"domain_scores_gemma":[0.9976121,0.0001573667,0.001546488,0.0001097715,0.0004518106,0.0001224336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004156025,0.0001362352,5.673955e-7,0.0008525873,0.001560674,0.0007868781,0.000007015305,0.000005090294,0.08265692,0.00001470721,0.07290981,0.841028],"study_design_scores_gemma":[0.0006548701,0.0003661734,2.71313e-7,0.001056697,0.00122335,0.01091995,0.00002503485,0.000001096765,0.03569532,0.00000776833,0.9498458,0.0002037071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001078388,0.993158,0.0001345553,0.00004021891,0.00517042,0.0002664353,0.00005033688,0.000002688242,0.00009898152],"genre_scores_gemma":[0.0006349417,0.9958267,0.0002307233,0.0001520959,0.002645405,0.00001977121,0.0000413523,0.00005568134,0.0003933055],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.876936,"threshold_uncertainty_score":0.9999981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053282789894591,"score_gpt":0.3364018860757461,"score_spread":0.3158690581768002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}