{"id":"W3165955961","doi":"10.1200/jco.2021.39.15_suppl.6014","title":"TRYHARD, a randomized phase II trial (RTOG Foundation 3501) of concurrent accelerated radiation plus cisplatin (cis) with or without lapatinib (Lap) for stage III- IV Non-HPV head and neck carcinoma (HNC).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Novartis","keywords":"Medicine; Clinical endpoint; Interim analysis; Internal medicine; Randomized controlled trial; Hazard ratio; Radiation therapy; Stage (stratigraphy); Progression-free survival; Oncology; Surgery; Confidence interval; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001618292,0.001510603,0.001910021,0.0006175001,0.0004687986,0.001059454,0.001067692,0.00173845,0.01038612],"category_scores_gemma":[0.001570649,0.0007584955,0.001324637,0.0003247134,0.001066897,0.001025488,0.0005589299,0.003349414,0.001241345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005996387,"about_ca_system_score_gemma":0.001444971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008757935,"about_ca_topic_score_gemma":0.002985434,"domain_scores_codex":[0.9994893,0.0002847233,0.00001935873,0.0001008871,0.00003623505,0.00006958924],"domain_scores_gemma":[0.999345,0.0001878198,0.0001142024,0.00005852963,0.00003239281,0.0002620051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9634811,0.009974183,0.0009117802,0.0005121363,0.0006907712,0.00005982378,0.00006814923,0.000766225,0.003639704,0.0002442264,0.001246068,0.01840589],"study_design_scores_gemma":[0.9619672,0.03584365,0.0008044372,0.00001402277,0.0001782227,0.00002102605,0.0000104131,0.000227518,0.0002253596,0.0001154574,0.0005859092,0.000006829618],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784172,0.002579034,0.0007682609,0.001168133,0.0005277492,0.009363268,0.001524124,0.0002256775,0.005426519],"genre_scores_gemma":[0.9725301,0.001608915,0.00198779,0.002371334,0.0002802932,0.01004005,0.00195439,0.00004517701,0.009182049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01038612,"threshold_uncertainty_score":0.03474498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1455570859181045,"score_gpt":0.5294386839519649,"score_spread":0.3838815980338605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}