{"id":"W3165960112","doi":"10.1200/jco.2021.39.15_suppl.e18616","title":"Optimism bias in the design of phase III randomized control trials (RCTs) evaluating PD-1/PD-L1 targeting monoclonal antibodies (mAbs).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Randomized controlled trial; Hazard ratio; Internal medicine; Monoclonal antibody; Confidence interval; Oncology; Clinical endpoint; Clinical trial; non-small cell lung cancer (NSCLC); Lung cancer; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7155288,0.002732949,0.01039204,0.007407567,0.001477096,0.009043083,0.004751548,0.008211576,0.00581713],"category_scores_gemma":[0.7987028,0.00259605,0.01340201,0.007291241,0.007057631,0.008664399,0.00472071,0.006910118,0.001472617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006163968,"about_ca_system_score_gemma":0.009159031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007166929,"about_ca_topic_score_gemma":0.001294242,"domain_scores_codex":[0.1110611,0.7629055,0.08792367,0.01686776,0.02005887,0.001182995],"domain_scores_gemma":[0.0826899,0.8232374,0.05108255,0.03032336,0.011636,0.001030872],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"systematic_review","study_design_gemma":"observational","study_design_scores_codex":[0.03848902,0.0006187918,0.0426008,0.3618775,0.1391085,0.001020462,0.006520692,0.008207253,0.002334696,0.07333115,0.0321863,0.2937049],"study_design_scores_gemma":[0.06681735,0.01090843,0.0382551,0.2011141,0.1246564,0.001765331,0.001754662,0.0389874,0.007048093,0.3399059,0.1674254,0.001361862],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.03094562,0.297563,0.4715407,0.04350668,0.02091356,0.108664,0.005949906,0.001626379,0.01929006],"genre_scores_gemma":[0.4171018,0.01675383,0.3631755,0.03258582,0.004686051,0.1617645,0.001921643,0.0003604759,0.001650411],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2844712,"threshold_uncertainty_score":0.3508037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8947952863249296,"score_gpt":0.7201853843460729,"score_spread":0.1746099019788566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}