{"id":"W3165960112","doi":"10.1200/jco.2021.39.15_suppl.e18616","title":"Optimism bias in the design of phase III randomized control trials (RCTs) evaluating PD-1/PD-L1 targeting monoclonal antibodies (mAbs).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Randomized controlled trial; Hazard ratio; Internal medicine; Monoclonal antibody; Confidence interval; Oncology; Clinical endpoint; Clinical trial; non-small cell lung cancer (NSCLC); Lung cancer; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4383512,0.0003731746,0.01253247,0.0001864433,0.0001030878,0.00005219937,0.0008128593,0.0008275659,0.0007647198],"category_scores_gemma":[0.9448312,0.000211814,0.002611691,0.0003798108,0.0009390558,0.0001389032,0.0001407228,0.002329303,0.000006743049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009342053,"about_ca_system_score_gemma":0.002588181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007826648,"about_ca_topic_score_gemma":0.000002460251,"domain_scores_codex":[0.8019812,0.1641007,0.03057239,0.0006292675,0.00196805,0.0007483982],"domain_scores_gemma":[0.09068836,0.8898245,0.01676269,0.0005103995,0.001909671,0.0003044503],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.7313229,0.01403453,0.0004848598,0.0003129387,0.005399372,0.002336037,0.001475048,0.003481688,0.003727288,0.03450192,0.01056498,0.1923584],"study_design_scores_gemma":[0.477835,0.0040606,0.0001121297,0.0003373575,0.00248752,0.0001005111,0.0005179367,0.01631773,0.0005220104,0.4971989,0.0002974597,0.0002128335],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2011855,0.001651383,0.7802129,0.008453226,0.004569037,0.002638158,0.00005101925,0.00002153818,0.001217263],"genre_scores_gemma":[0.1863509,0.001043698,0.8089414,0.00150741,0.002036863,0.00003835366,0.000001221377,0.0000339186,0.00004623561],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.7257237,"threshold_uncertainty_score":0.9999723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8947952863249296,"score_gpt":0.7201853843460729,"score_spread":0.1746099019788566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}