{"id":"W3166054274","doi":"10.1016/j.ccell.2021.05.007","title":"STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma","year":2021,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Dalhousie University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Dana-Farber Cancer Institute; St. Baldrick's Foundation; U.S. Department of Defense","keywords":"Cohesin; Enhancer; Chromatin; Biology; Reprogramming; Cancer research; Transcription factor; Cell biology; PRC2; Phenotype; EZH2; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169059,0.0002652462,0.0002141994,0.0004687682,0.0002077026,0.0005631767,0.000293468,0.0004070101,0.002044029],"category_scores_gemma":[0.0001667157,0.0002797871,0.0002790928,0.0002890583,0.0003514974,0.0002583786,0.0003931902,0.000829658,0.000725137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004503484,"about_ca_system_score_gemma":0.0003490226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331577,"about_ca_topic_score_gemma":0.003877426,"domain_scores_codex":[0.999879,0.00001249406,0.00001043102,0.00002475742,0.00004037025,0.00003277837],"domain_scores_gemma":[0.9998876,0.00001408935,0.00002430106,0.00002151415,0.00000819267,0.00004428215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00017227,0.00003625932,0.000986354,0.0000295796,0.00001378652,0.0001671113,0.00002186703,0.0003675299,0.9943998,0.000755525,0.0004550013,0.002594868],"study_design_scores_gemma":[0.00005078054,0.0001666523,0.02813068,0.00001022823,0.00004766561,0.0008433516,0.0001374536,0.005981314,0.9507943,0.0005785226,0.01324419,0.00001484329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930078,0.0009845882,0.002043247,0.0003904525,0.00008317019,0.00001189178,0.000738996,0.0002903478,0.002449588],"genre_scores_gemma":[0.9958931,0.0002462763,0.0003604014,0.00009341346,0.00000731578,0.000008699957,0.0003744932,0.00005147228,0.002964754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002044029,"threshold_uncertainty_score":0.006837964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169609014428263,"score_gpt":0.2435269432675544,"score_spread":0.2318308531232717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}