{"id":"W3166054274","doi":"10.1016/j.ccell.2021.05.007","title":"STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma","year":2021,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Dalhousie University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Dana-Farber Cancer Institute; St. Baldrick's Foundation; U.S. Department of Defense","keywords":"Cohesin; Enhancer; Chromatin; Biology; Reprogramming; Cancer research; Transcription factor; Cell biology; PRC2; Phenotype; EZH2; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007095873,0.0001102877,0.0001151487,0.00001389874,0.0000370684,0.00003304538,0.00008633789,0.00005895395,0.000025074],"category_scores_gemma":[0.000008185726,0.0001163132,0.00003260842,0.00008234568,0.00002072669,0.000002634443,0.0001743484,0.00004555294,0.000002886969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007566916,"about_ca_system_score_gemma":0.0001919972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009214036,"about_ca_topic_score_gemma":0.001468737,"domain_scores_codex":[0.9992554,0.00001929177,0.000144474,0.0003070612,0.00006285164,0.0002109819],"domain_scores_gemma":[0.9997181,0.000002338272,0.00002966994,0.0001327137,0.00003723274,0.00007998392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002108797,0.00007536053,0.009943021,0.00006404572,0.00003995708,0.00003269228,0.0003896824,0.00003819915,0.9264847,0.00000959416,0.0001304135,0.06277123],"study_design_scores_gemma":[0.0006128958,0.000105517,0.002547581,0.00003806517,0.00001772642,0.0000278495,0.0005864531,0.00009252366,0.9397655,0.00003923731,0.05588966,0.0002769871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954042,0.003659722,0.00008420082,0.00009319412,0.00006525884,0.0001564935,0.00002369279,0.000004710381,0.000508529],"genre_scores_gemma":[0.9899006,0.0007532432,0.008396625,0.000190018,0.00004566467,0.00004811714,0.00006413713,0.00001987628,0.000581708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06249424,"threshold_uncertainty_score":0.4743114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169609014428263,"score_gpt":0.2435269432675544,"score_spread":0.2318308531232717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}